Planta Med 2019; 85(18): 1545
DOI: 10.1055/s-0039-3400081
Main Congress Poster
Poster Session 2
© Georg Thieme Verlag KG Stuttgart · New York

Rose essential oils stimulate neural differentiation and autophagy in stem cells

I Sasanuma
1   Department of Materials Chemistry and Bioengineering, National Institute of Technology, Oyama College,, 771 Nakakuki, Oyama, Japan
,
N Suzuki
1   Department of Materials Chemistry and Bioengineering, National Institute of Technology, Oyama College,, 771 Nakakuki, Oyama, Japan
,
K Saito
1   Department of Materials Chemistry and Bioengineering, National Institute of Technology, Oyama College,, 771 Nakakuki, Oyama, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
20 December 2019 (online)

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    Lysosomes of stem cells are essential for maintaining cellular homeostasis, and dysfunction of the organelles has been observed in multiple cranial nerve diseases. Stem cells of olfactory bulb are highly dynamic and undergo fission and differentiation to maintain a functional nerve network. Here we have identified the formation and regulation of glycosylation of protein using zymogram, filter retardation assay and PA-staining. Glycosylation of protein formed in aromas untreated cells and were distinct from damaged protein that were targeted into lysosomes for degradation. Glycosylation was promoted in active 100kD receptor, and glycosylation untethering was mediated by recruitment of β-glucosidase to extracellular by geraniol to drive sugar chain hydrolysis and thereby inactivates the receptor. Functionally, glycosylation marks sites proliferation and differentiation of stem cells, allowing regulation of neural networks by stem cells, whereas conversely, glycosylation regulates receptor activity via β-glucosidase. Glycosylation thus allows directional regulation of receptor dynamics, and may explain the dysfunction observed in lysosome in various human diseases.


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