It has been brought to the publisher's attention, that there was an error in Table 1 of the above article, published in TH Open, Volume 3, Number 3, 2019, pages e309–e315 (DOI: 10.1055/s-0039-1696659). In the SELECT-D study, it should state “N = 406” instead of “N = 203”.
The correct table appears below.
Table 1
Protocol design of randomized control trials on anticoagulants for the treatment of cancer-associated thrombosis
Study (year)
|
Study drug/comparator
|
Patients
|
Methods/statistics
|
Primary endpoint
|
Secondary endpoints
|
Duration (mo)
|
ONCENOX39
N = 122 (2006)
|
Enoxaparin/warfarin
|
Active cancer, acute symptomatic VTE
|
Pilot feasibility
|
VTE recurrence
|
Major and minor bleeding
|
6
|
CANTHANOX25
N = 146 (2002)
|
Enoxaparin/warfarin
|
Active or treated cancer, PE, and/or DVT
|
S
|
Composite of major bleeding or recurrent VTE
|
Recurrent VTE
Major bleeding
|
3
|
CLOT26
N = 672 (2003)
|
Dalteparin/warfarin
|
Active cancers, acute proximal symptomatic DVT or PE
|
Phase III/S
|
Symptomatic recurrence of DVT, PE, or both
|
Major bleeding
Any bleeding
|
6
|
LITE CANCER27
N = 200 (2006)
|
Tinzaparin/warfarin
|
Cancer, acute proximal DVT
|
Phase III/S
|
Recurrent VTE or death
|
Major and minor bleeding
|
3
|
CATCH22
N = 900 (2015)
|
Tinzaparin/warfarin
|
Active cancers, acute proximal symptomatic DVT or PE
|
Phase III/S
|
VTE recurrence: proximal DVT, PE either symptomatic or incidental
|
Major bleeding
CRNMB
|
6
|
SELECT-D23
N = 406 (2018)
|
Rivaroxaban/dalteparin
|
All active cancers, proximal DVT, PE, incidental PE
|
Pilot
|
VTE recurrence: proximal DVT, PE either symptomatic or incidental, and other sites
|
Major bleeding
CRNMB
|
6
|
HOKUSAI-VTE Cancer21
N = 1,046 (2018)
|
Edoxaban/dalteparin
|
Active or history of cancer, acute symptomatic or incidental VTE
|
Phase III/NI
|
Composite of VTE recurrence (symptomatic or incidental) or major bleeding
|
VTE recurrence
Major bleeding
CRNMB
|
12
|
CARAVAGGIO35
N = 1,168 (2019)
|
Apixaban/dalteparin
|
Active or history of cancer, symptomatic or incidental proximal DVT or PE
|
Phase III/NI
|
Symptomatic or incidental VTE recurrence
|
Major bleeding
|
6
|
Abbreviations: CRNMB, clinically relevant nonmajor bleeding; DVT, deep-vein thrombosis; NI, noninferiority trial; PE, pulmonary embolism; S, superiority trial; VTE, venous thromboembolism.