EFFICACY AND SAFETY OF SODIUM PICOSULFATE-MAGNESIUM CITRATE IN BOWEL PREPARATION FOR ELDERLY IN KOREAN POPULATION: A PILOT STUDY

SH Kim; KW Lee; S Kim; SH Jang; HJ Jeon; SJ Choi; JM Lee; HS Choi; ES Kim; B Keum; YT Jeen; HS Lee; HJ Chun; CD Kim

doi:10.1055/s-0040-1704597

Endoscopy, Table of Contents

Endoscopy 2020; 52(S 01): S192
DOI: 10.1055/s-0040-1704597

ESGE Days 2020 ePoster Podium presentations

Friday, April 24, 2020 15:00 – 15:30 Standards of endoscopy ePoster Podium 4

EFFICACY AND SAFETY OF SODIUM PICOSULFATE-MAGNESIUM CITRATE IN BOWEL PREPARATION FOR ELDERLY IN KOREAN POPULATION: A PILOT STUDY

Authors

SH Kim

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
KW Lee

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
S Kim

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
SH Jang

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
HJ Jeon

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
SJ Choi

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
JM Lee

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
HS Choi

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
ES Kim

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
B Keum

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
YT Jeen

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
HS Lee

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
HJ Chun

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of
CD Kim

¹Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, Korea, Republic of

Abstract

Full Text

Aims Bowel preparation is one of the most important colonoscopy quality indicators. Sodium picosulfate-magnesium citrate (SP-MC) is getting more attention for its better tolerance and patient satisfaction compared to PEG-based solutions. However, its efficacy and safety in elderly patients has not been verified enough in Korean population. We compared the efficacy and safety of SP-MC compared to polyethyleneglycol (PEG) based bowel preparations in the elderly.

Methods A prospective, randomized, controlled trial was conducted at Korea University Anam Hospital. 70 outpatients and 68 inpatients who were over 65 years of age randomized to either PEG or SP-MC group. Bowel preparation quality was recorded in a blinded manner by the endoscopist using the Boston Bowel Preparation Scale (BBPS). Patient satisfaction was studied by questionnaire before colonoscopy. Side effects including hyponatremia and acute kidney injury were monitored by laboratory test following bowel preparation.

Results Baseline characteristics between the two groups were similar. BBPS score did not defer significantly between the two groups (PEG: SPMC, 6.97: 7.49, P = 0.131). Adenoma detection rates were also similar (PEG: SPMC, 51.5%: 52.9%, P = 0.805). Proportion of patients who answered more satisfactory than previous bowel preparation were higher in the SPMC group (24.3% vs 60.2%, P < 0.001). There was no reported acute kidney injury or electrolyte imbalance following preparation in both groups.

Conclusions Bowel preparation quality with the use of SP-MC was not inferior to PEG based preparation with even better patient satisfaction. Incidence of electrolyte imbalance or decline in renal function was not observed. SPMC is expected to be safely used in elderly without chronic renal diseases.