Endoscopy 2020; 52(S 01): S321
DOI: 10.1055/s-0040-1705035
ESGE Days 2020 ePoster presentations
Thursday, April 23, 2020 09:00-17:00 Pediatric endoscopy ePoster area
© Georg Thieme Verlag KG Stuttgart · New York

SAFETY OF ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY IN PEDIATRIC POPULATION: A MULTICENTER STUDY

Authors

  • M Schaefer

    17   Regional University Hospital of Nancy, Department of Endoscopy and Hepatogastroenterology, Nancy, France

  • C Mercier

    1   Children’s University Hospital of Nancy, Department of Pediatric Gastroenterology Hepatology and Nutrition, Vandoeuvre-Lès-Nancy, France

  • M Pioche

    2   Edouard Herriot University Hospital, Department of Endoscopy and Gastroenterology, Lyon, France

  • E Albuisson

    3   Regional University Hospital of Nancy, Département MPI, Unité de Méthodologie, Data management et Statistique UMDS, Nancy, France

  • T Ponchon

    2   Edouard Herriot University Hospital, Department of Endoscopy and Gastroenterology, Lyon, France

  • JM Gonzalez

    4   Aix-Marseille Université, AP-HM, Hôpital Nord, Department of Digestive Endoscopy, Marseille, France

  • M Barthet

    4   Aix-Marseille Université, AP-HM, Hôpital Nord, Department of Digestive Endoscopy, Marseille, France

  • I Boytchev

    5   Kremlin-Bicêtre University Hospital, Gastroenterology Department, Paris, France

  • G Vanbiervliet

    6   University Hospital Hassan II, Faculty of Medicine and Pharmacy of Fez, Gastroenterology Department, Nice, France

  • F Prat

    7   Cochin Hospital, Department of Gastroenterology, Paris, France

  • A Belle

    7   Cochin Hospital, Department of Gastroenterology, Paris, France

  • J Branche

    8   Claude Huriez Hospital, Gastroenterology Department, Lille, France

  • P Grandval

    9   AP-HM, Hôpital La Timone, Hepatogastroenterology Department, Marseille, France

  • JC Valats

    10   Lapeyronie Hospital, Department of Endoscopy and Gastroenterology, Montpellier, France

  • F Rudler

    10   Lapeyronie Hospital, Department of Endoscopy and Gastroenterology, Montpellier, France

  • T Wallenhorst

    11   University Hospital of Rennes, Department of Gastroenterology, Pontchaillou Rennes, France

  • S Koch

    12   University Hospital of Besançon, Department of Gastroenterology, Besançon, France

  • A Comte

    13   University Hospital of Besançon, Department of Pediatric Hepatology, Gastroenterology and Nutrition, Besançon, France

  • N Williet

    14   University Hospital of Saint-Etienne, Department of Hepato-Gastro-Enterology, Saint-Etienne, France

  • N Musquer

    15   Nantes University Hospital, Digestive Endoscopy Department, Nantes, France

  • E Coron

    15   Nantes University Hospital, Digestive Endoscopy Department, Nantes, France

  • JP Le Mouel

    16   Amiens University Hospital, Gastroenterology, Amiens, France

  • I Scheers

    18   Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Department of Pediatric Gastroenterology and Hepatology, Brussels, Belgium

  • P Deprez

    19   Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Department of Hepatogastroenterology, Brussels, Belgium

  • JB Chevaux

    17   Regional University Hospital of Nancy, Department of Endoscopy and Hepatogastroenterology, Nancy, France
Further Information

Publication History

Publication Date:
23 April 2020 (online)

Also available at
 
 

Aims Endoscopic retrograde cholangiopancreatography (ERCP) has an important role in pediatric pancreaticobiliary diseases. The aims of this retrospective multicenter study were to assess the technical success and adverse events of ERCPs in children in French and Belgian centers.

Methods All children aged from one day to seventeen years old who underwent ERCP between January 2008 and March 2019 in 15 tertiary care hospitals were retrospectively included.

Results 271 children underwent 470 ERCP. Median age at intervention was 10.9 years. Multiple ERCP were performed on 30% patients (81/271). ERCP were therapeutic in 90% (423/470) and diagnostic only, in case of neonatal cholestasis, in 10%. Proportions of biliary and pancreatic indications were 63% and 37% respectively. Most common biliary indication was choledocholithiasis and most common pancreatic indication was chronic pancreatitis. Biliary cannulation was successful in 92% of cases (270/294), pancreatic cannulation in 96% (169/176) and planned therapeutic procedure was successful in 91% (388/423). The overall complication rate was 19% (65/340). Most common complication was post-ERCP pancreatitis (PEP) in 12% (40/340) and sepsis in 5% (18/340). In multivariate analysis, pancreatic stent removal was protective against PEP

(OR 0.066; 95% CI: 0.005;0.826, p=0.035) and sepsis was associated with liver transplantation history (OR 8.64, 95% CI: 1.648;45.305, p=0.011). Five patients had post-ERCP hemorrhage and two had intestinal perforation. All complications were successfully managed with supportive medical care. There was no procedure-related mortality. There was no post sphincterotomy cholangiocarcinoma reported nor cancer radio-induced reported throughout the study period.

Conclusions Our cohort demonstrates that ERCP can be performed safely with high success rates in many pancreaticobiliary diseases of children. The rate of adverse events was similar to previous reports and no serious adverse events occurred. The beneficial impact of ERCP in this large multicentric pediatric cohort is highlighted.