Methanesulfonic Acid Catalyzed Friedel–Crafts Reaction of Electron-Rich Arenes with N-Arylmaleimides: A Highly Efficient Metal-Free Route To Access 3-Arylsuccinimides

Abstract

Friedel–Crafts reaction is widely used for the C–C bond forming reaction to enable the direct connection of electron-rich arenes to electron-deficient olefins with high regioselectivity. Herein, a highly efficient, metal-free, and environmentally benign F–C strategy of electron-rich arenes with N-arylmaleimides has been developed for the construction of 3-arylsuccinimides in the presence of a green reagent methanesulfonic acid under mild reaction conditions. This highly facile and high-yielding protocol has compatibility with different electron-rich arenes.

Key words

Friedel–Crafts reaction - C-3 arylation - metal-free - green reagent - 3-arylsuccinimides

• References

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