Ruthenium-Catalyzed Oxidative Dearomatization of N-Boc Indoles

Abstract

Ruthenium-catalyzed oxidative dearomatization of N-Boc indoles for the synthesis of indolin-3-ones is described. The N-Boc indoles can be transformed into indolin-3-ones in acetonitrile, using RuCl­₃·3H₂O as catalyst and sodium periodate (1.5 equiv) as oxidant. Further, a possible mechanism has been proposed on the basis of control experiments.

Key words

ruthenium - oxidative dearomatization - indoles - indolin-3-ones - sodium periodate

Publication History

Received: 01 September 2020

Accepted after revision: 18 September 2020

Article published online:
19 October 2020

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