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Synthesis 2021; 53(06): 1121-1126
DOI: 10.1055/s-0040-1706539
DOI: 10.1055/s-0040-1706539
paper
Ruthenium-Catalyzed Oxidative Dearomatization of N-Boc Indoles
Authors
This work was supported by the Foundation of Guizhou Educational Committee (Grant No. qianjiaohe KY zi [2019]081), the Natural Science Foundation of Guizhou Province (Grant No. qiankehejichu [2018]1141) and the Natural Science Foundation of Liupanshui City (Grant No. 52020-2018-04-10).
Abstract
Ruthenium-catalyzed oxidative dearomatization of N-Boc indoles for the synthesis of indolin-3-ones is described. The N-Boc indoles can be transformed into indolin-3-ones in acetonitrile, using RuCl3·3H2O as catalyst and sodium periodate (1.5 equiv) as oxidant. Further, a possible mechanism has been proposed on the basis of control experiments.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1706539.
- Supporting Information (PDF)
Publication History
Received: 01 September 2020
Accepted after revision: 18 September 2020
Article published online:
19 October 2020
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