Recent Applications of Continuous Flow in Homogeneous Palladium Catalysis

Martin Markovič; Pavol Lopatka; Tibor Gracza; Peter Koóš

doi:10.1055/s-0040-1707212

Synthesis, Table of Contents

Synthesis 2020; 52(23): 3511-3529
DOI: 10.1055/s-0040-1707212

review

Recent Applications of Continuous Flow in Homogeneous Palladium Catalysis

Martin Markovič

^aDepartment of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia Email: peter.koos@stuba.sk

^bGeorganics Ltd., Koreničova 1, 811 03 Bratislava, Slovakia

,

Pavol Lopatka

^bGeorganics Ltd., Koreničova 1, 811 03 Bratislava, Slovakia

,

Tibor Gracza

^aDepartment of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia Email: peter.koos@stuba.sk

,

Peter Koóš ∗

^aDepartment of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia Email: peter.koos@stuba.sk

^bGeorganics Ltd., Koreničova 1, 811 03 Bratislava, Slovakia

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Abstract

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Abstract

Considerable advances have been made using continuous flow chemistry as an enabling tool in organic synthesis. Consequently, the number of articles reporting continuous flow methods has increased significantly in recent years. This review covers the progress achieved in homogeneous palladium catalysis using continuous flow conditions over the last five years, including C–C/C–N cross-coupling reactions, carbonylations and reductive/oxidative transformations.

1 Introduction

2 C–C Cross-Coupling Reactions

3 C–N Coupling Reactions

4 Carbonylation Reactions

5 Miscellaneous Reactions

6 Key to Schematic Symbols

7 Conclusion

Key words

flow chemistry - homogeneous catalysis - palladium - cross-coupling - Buchwald–Hartwig - carbonylation - oxidation - reduction

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References

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