Synthetic Approaches to Acyl Hydrazides and Their Use as Synthons in Organic Synthesis

Nikoleta Spiliopoulou; Constantinos T. Constantinou; Ierasia Triandafillidi; Christoforos G. Kokotos

doi:10.1055/s-0040-1707394

Synthesis, Table of Contents

Synthesis 2020; 52(21): 3219-3230
DOI: 10.1055/s-0040-1707394

special topic

Synthetic Approaches to Acyl Hydrazides and Their Use as Synthons in Organic Synthesis

Nikoleta Spiliopoulou

,

Constantinos T. Constantinou

,

Ierasia Triandafillidi∗

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis 15784, Athens, Greece Email: iertriant@chem.uoa.gr Email: ckokotos@chem.uoa.gr

,

Christoforos G. Kokotos∗

Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis 15784, Athens, Greece Email: iertriant@chem.uoa.gr Email: ckokotos@chem.uoa.gr

› Author Affiliations

Abstract

All articles of this category

Published as part of the Special Topic Recent Advances in Amide Bond Formation

Abstract

Acyl hydrazides constitute very important moieties in organic chemistry and have been employed as starting materials for different transformations to many classes of organic compounds. In this review, at first the approaches towards the synthesis of acyl hydrazides are presented. Furthermore, in the second part, the uses of this skeleton as an important intermediate for the synthesis of useful organic compounds are analyzed.

1 Introduction

2 Approaches towards the Synthesis of Acyl Hydrazides

2.1 Synthesis of Acyl Hydrazides from Aldehydes

2.2 Synthesis of Acyl Hydrazides from Carboxylic Acid Derivatives

3 Acyl Hydrazides as Useful Synthons in Synthetic Organic Transfor mations

3.1 Acyl Hydrazides as Synthetic Precursors for the Synthesis of Car bonyl Compounds

3.2 Acyl Hydrazides as Synthetic Precursors for the Synthesis of Het erocyclic Rings

4 Conclusion

Key words

acyl hydrazides - aldehydes - azodicarboxylates - synthons - intermediates

Full Text

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