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Synthesis 2020; 52(16): 2379-2386
DOI: 10.1055/s-0040-1707395
DOI: 10.1055/s-0040-1707395
paper
Gold-Catalyzed Partial Hydrogenation of Activated Alkynes Mediated by Triphenylphosphine
This work was supported by CONACyT (A1-S-7805) and DGAPA (IN202017).Further Information
Publication History
Received: 15 March 2020
Accepted after revision: 08 April 2020
Publication Date:
12 May 2020 (online)
Abstract
Gold(I) can exhibit a cooperative effect with triphenylphosphine, accelerating the triphenylphosphine-mediated partial hydrogenation of activated alkynes. In this protocol, 3-arylpropiolates are selectively reduced to the Z-isomer when the aryl ring bears an electron-donor substituent, whereas 3-arylpropynones are reduced to the E-isomers.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707395.
- Supporting Information