Abstract Background The pathophysiology of AERD is still a matter of debate. Oral Aspirin provocations
tests are the diagnostic method of choice so far. However, provocation tests do not
analyse the induvial arachidonic acid metabolism. In contrast the functional eicosanoid
blood test can identify individuals suffering from AERD even without asthma.
Which test parameters are most suitable to estimate a successful aspirin desensitization
and which parameters correlate with clinical symptoms are unknown.
The aim of the study is to identify in vitro parameters which are suitable parameters
during therapy and which should help to implement an individual dose depended aspirin
desensitization in the future.
Methods 16 patients were analysed within a prospective clinical trial. All patients had undergone
sinus surgery due to chronic rhinosinusitis followed by aspirin desensitization.
Functional eicosanoid testing was repeated and in-vitro parameters of the arachidonic
acid metabolism such as leukotrienes, prostaglandins and neuropeptide prostaglandin
were analysed and correlated to patients’ clinical symptoms, nasal endoscopy and quality
of life.
Results The study provides a closer insight into the arachidonic acid metabolisms and its
products in relation to the clinical symptoms. Further we identified parameters which
are most suitable to estimate a successful aspirin desensitization
Summary
In the future the identified in vitro-parameters should help to perform and individual
aspirin desensitization with an individual aspirin maintenance dose as low as possible.
Poster-PDF
A-1824.PDF
