CC BY-NC-ND 4.0 · Laryngorhinootologie 2020; 99(S 02): S161
DOI: 10.1055/s-0040-1711019
Abstracts
Oncology

Investigation of head and neck tumors with 68Ga-FAPI, the new radiotracer

Y Zhi
1   Klinik und Poliklinik für Hals-, Nasen-, und Ohrenkrankheiten, plastische und ästhetische Operationen Würzburg
,
S Serfling
2   Klinik und Poliklinik für Nuklearmedizin Würzburg
,
A Buck
2   Klinik und Poliklinik für Nuklearmedizin Würzburg
,
E Gerhard-Hartmann
3   Universität Würzburg, Pathologisches Institut Würzburg
,
A Scherzad
1   Klinik und Poliklinik für Hals-, Nasen-, und Ohrenkrankheiten, plastische und ästhetische Operationen Würzburg
,
R Hagen
1   Klinik und Poliklinik für Hals-, Nasen-, und Ohrenkrankheiten, plastische und ästhetische Operationen Würzburg
,
S Hackenberg
1   Klinik und Poliklinik für Hals-, Nasen-, und Ohrenkrankheiten, plastische und ästhetische Operationen Würzburg
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    Introduction Positron-emission-tomography-computer tomography (PET-CT) with 18F-FDG as standard tracer is used for the preoperative staging of head and neck tumors, especially for the diagnosis of CUP (Cancer of Unknown Primary). However, in diagnosis of Waldeyer's pharyngeal rings using 18F-FDG it is not possible to distinguish between chronically inflamed and tumor tissues. The fibroblast activation protein (FAP) is overexpressed in tumor-associated fibroblasts (CAF), but not in healthy tissues, or in tissues with chronic inflammation. The aim of this study was to compare a new radiotracer, 68Ga-FAPI that interacts selectively with FAP, with 18F-FDG for the diagnosis of head and neck cancer.

    Material and Methods In this study, six patients with suspicion of tonsil cancer were included. 18F-FDG and 68Ga-FAPI-PET/CT assays were performed pre-operatively. Afterwards, the Results from the histopathological examination of resected tumors and neck dissection specimens were compared with the Results of PET-CT images.

    Conclusions Histopathological examinations confirmed that all patients had a tonsil cancer with regional lymph node metastasis. In PET-CTs, all tonsil cancers showed an intensive uptake of both tracers. In contrast to the uptake of 18F-FDG the healthy tonsil tissues didn`t shown any uptake of 68Ga-FAPI tracer. Immuno-histochemical stains of tissue sections with an antibody raised against FAP confirmed the Results of 68Ga-FAPI-PET-CT, i.e. only tumor tissues that incorporated 68Ga-FAPI were stained positively by the antibody.

    Summary The standard PET-tracer 18F-FDG is not tumor-specific. In contrast, the use of the 68Ga-FAPI tracer Results in tumor-specific images. So it may allow for a precise detection of head and neck tumors with high specificity.

    Poster-PDF A-1193.PDF


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    Dr. med Zhi Yingjun
    Klinik und Poliklinik für Hals-, Nasen-, und Ohrenkrankheiten, plastische und ästhetische Operationen
    Josef-Schneider-Str.11
    97080 Würzburg
    eMail: Zhi_Y@ukw.de

    Publikationsverlauf

    Artikel online veröffentlicht:
    10. Juni 2020

    © 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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