Direct Synthesis of Disubstituted Trifluoromethylthiolated Alkenes

Dedicated to Prof. Ferenc Fülöp

Abstract

In the field of organofluorine chemistry, the quest for emergent fluorinated groups is in high demand. In particular, the scientific community has shown special interest in the SCF₃ residue thanks to its unique properties. Indeed, over the last decade, the SCF₃ group has become a pivotal fluorinated moiety, as demonstrated by several SCF₃-containing compounds of interest, and, related to that, the steadily increasing number of synthetic methods that are available to access such molecules. In this Short Review, the main advances made for the synthesis of trifluoromethylthiolated disubstituted alkenes will be discussed and highlighted.

1 Introduction

2 Trifluoromethylthiolation of Prefunctionalized Alkenes

3 Direct C–H Trifluoromethylthiolation of Alkenes

4 Trifluoromethylthiolation of Miscellaneous Derivatives

5 Conclusion

Key words,

trifluoromethylthiolation - synthetic methodologies - organofluorine chemistry - disubstituted olefins - homogeneous catalysis - transition-metal-free reactions

Publication History

Received: 22 November 2021

Accepted after revision: 20 December 2021

Article published online:
01 March 2022

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