De novo Crohn disease after liver transplantation: Case Report and Review of the literature

Although, inflammatory bowel disease (IBD) is an important differential diagnosis yet in patients with immunosuppressive treatment, especially calcineurin-inhibitors, only very few patients are reported. We present a patient with de novo Crohn disease (CD) after liver transplantation. The patient was diagnosed under immunosuppressive treatment after antecedent liver transplantation due to polycystic liver and kidney disease. Our patient suffered from abdominal pain, chronic diarrhea and episodes of fever and shivering for months until the diagnosis of CD was made and intensification of immunosuppressive treatment led to improvement of symptoms. Treatment with additional or increased corticosteroids is feasible and may lead to rapid response. In order to foster the discussion on those mechanisms we furthermore bring our case in perspective with the available literature.

Publication History

Article published online:
04 January 2021