PSYCH up2date, Table of Contents PSYCH up2date 2015; 9(05): 265-280DOI: 10.1055/s-0041-102941 Organische psychische Störungen © Georg Thieme Verlag KG Stuttgart · New York Depressionen und Psychosen bei immunologischen Enzephalopathien Ludger Tebartz van Elst , Oliver Stich , Dominique Endres Recommend Article Abstract Buy Article All articles of this category Full Text References Literatur 1 Roeder F. Über die serologische Diagnostik der Schizophrenie aus dem Liquor nach der Methode von Lehmann-Facius. Z Gesamte Neurol Psychiatr 1939; 165: 462-467 2 Bechter K. Updating the mild encephalitis hypothesis of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2013; 42: 71-91 3 van Elst LT, Klöppel S, Rauer S. Voltage-gated potassium channel/LGI1 antibody-associated encephalopathy may cause brief psychotic disorder. J Clin Psychiatry 2011; 72: 722-723 4 Endres D, Perlov E, Stich O et al. Hypoglutamatergic state is associated with reduced cerebral glucose metabolism in anti-NMDA receptor encephalitis. BMC Psychiatry 2015; [in submission] 5 Endres D, Perlov E, Stich O et al. Case report: low-titre anti-Yo reactivity in a female patient with psychotic syndrome and frontoparieto-cerebellar atrophy. BMC Psychiatry 2015; 15: 112 6 Endres D, Perlov E, Stich O et al. Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) – presenting as major depression. BMC Psychiatry 2015; [in submission] 7 Stich O, Rauer S. Paraneoplastische neurologische Syndrome und Autoimmunenzephalitiden. Nervenarzt 2014; 85: 485-498; quiz 499–501 8 Titulaer MJ, McCracken L, Gabilondo I et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013; 12: 157-165 9 Bien CG, Bauer J. Pathophysiologie antikörperassoziierter ZNS-Erkrankungen. Nervenarzt 2013; 84: 466-470 10 Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y et al. Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis. Neurology 2011; 77: 589-593 11 Armangue T, Leypoldt F, Málaga I et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 2014; 75: 317-323 12 Dalmau J, Lancaster E, Martinez-Hernandez E et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011; 10: 63-74 13 Ramanathan S, Mohammad SS, Brilot F et al. Autoimmune encephalitis: Recent updates and emerging challenges. J Clin Neurosci 2014; 21: 722-730 14 Stich O, Jarius S, Kleer B et al. Specific antibody index in cerebrospinal fluid from patients with central and peripheral paraneoplastic neurological syndromes. J Neuroimmunol 2007; 183: 220-224 15 Dalmau J, Gleichman AJ, Hughes EG et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091-1098 16 Castillo P, Woodruff B, Caselli R et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol 2006; 63: 197-202 17 Tebartz van Elst L, Krishnamoorthy ES, Schulze-Bonhage A et al. Local area network inhibition: a model of a potentially important paraepileptic pathomechanism in neuropsychiatric disorders. Epilepsy Behav 2011; 22: 231-239 18 Tebartz van Elst L, Maier S, Fangmeier T et al. Disturbed cingulate glutamate metabolism in adults with high-functioning autism spectrum disorder: evidence in support of the excitatory/inhibitory imbalance hypothesis. Mol Psychiatry 2014; 19: 1314-1325 19 Tebartz van Elst L, Maier S, Fangmeier T et al. Magnetic resonance spectroscopy comparing adults with high functioning autism and above average IQ. Mol Psychiatry 2014; 19: 1251 20 Tebartz van Elst L, Perlov E. Epilepsie und Psyche: Psychische Störungen bei Epilepsie – epileptische Phänomene in der Psychiatrie. 1st. ed. Stuttgart: Kohlhammer; 2013 21 Bien C. Immunvermittelte Erkrankungen der grauen ZNS-Substanz sowie Neurosarkoidose: S1-Leitlinie. Leitlinien für Diagnostik und Therapie in der Neurologie 2012. Im Internet: www.dgn.org/leitlinien-online-2012/inhalte-nach-kapitel/2396-ll-32-2012-immunvermittelte-erkrankungen-der-grauen-zns-substanz-sowie-neurosarkoidose.html (Stand: 9.7.15) 22 Bien CG. Antikörperassoziierte Erkrankungen der grauen Substanz des ZNS: Diagnostik und Therapie. Nervenarzt 2011; 82: 986-993 23 Graus F, Dalmau J. Paraneoplastic neurological syndromes. Curr Opin Neurol 2012; 25: 795-801 24 Kayser MS, Kohler CG, Dalmau J. Psychiatric manifestations of paraneoplastic disorders. Am J Psychiatry 2010; 167: 1039-1050 25 Baumgartner A, Rauer S, Mader I et al. Cerebral FDG-PET and MRI findings in autoimmune limbic encephalitis: correlation with autoantibody types. J Neurol 2013; 260: 2744-2753 26 Brain L, Jellinek EH, Ball K. Hashimoto’s disease and encephalopathy. Lancet 1966; 2: 512-514 27 Chang Y, Kuo Y, Wu P et al. The misdiagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis as masked depression in an elderly euthyroid woman. Psychosomatics 2013; 54: 599-603 28 Lin Y, Liao S. Hashimoto encephalopathy presenting as schizophrenia-like disorder. Cogn Behav Neurol 2009; 22: 197-201 29 Ramalho JCM. Hashimoto’s encephalopathy. Radiology Case Reports 2011; 31: 445 30 Dalakas MC. Stiff person syndrome: advances in pathogenesis and therapeutic interventions. Curr Treat Options Neurol 2009; 11: 102-110 31 Baizabal-Carvallo JF, Jankovic J. Stiff-person syndrome: insights into a complex autoimmune disorder. J Neurol Neurosurg Psychiatr 2014; [Epub ahead of print] 32 Raju R, Foote J, Banga JP et al. Analysis of GAD65 autoantibodies in Stiff-Person syndrome patients. J Immunol 2005; 175: 7755-7762 33 Leypoldt F, Armangue T, Dalmau J. Autoimmune encephalopathies. Ann NY Acad Sci 2015; 1338: 94-114 34 Meinck HM. Stiff-Man-Syndrom (Synonym: Stiff-Person-Syndrome): S1-Leitlinie. 2012. Im Internet: www.dgn.org/leitlinien/2410-ll-70-2012-stiff-man-syndrom-synonym-stiff-person-syndrom (Stand: 9.7.15) 35 Peterson K, Rosenblum MK, Kotanides H et al. Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 1992; 42: 1931-1937 36 Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain 1998; 121: 561-579 37 Stich O, Rauer S, Kaiser R. Paraneoplastische und fakultativ-paraneoplastische neurologische Erkrankungen. In: Neurologie compact – Für Klinik und Praxis. Baltimore: Thieme; 2013 38 Granerod J, Ambrose HE, Davies NW et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis 2010; 10: 835-844 39 Prüss H, Dalmau J, Arolt V et al. Anti-NMDA-Rezeptor-Enzephalitis. Ein interdisziplinäres Krankheitsbild. Nervenarzt 2010; 81: 396-408 40 Steiner J, Walter M, Glanz W et al. Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 2013; 70: 271-278 41 Hammer C, Stepniak B, Schneider A et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 2014; 19: 1143-1149 42 Schmitt SE, Pargeon K, Frechette ES et al. Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology 2012; 79: 1094-1100 43 Somers KJ, Lennon VA, Rundell JR et al. Psychiatric manifestations of voltage-gated potassium-channel complex autoimmunity. J Neuropsychiatry Clin Neurosci 2011; 23: 425-433 44 Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S et al. Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet 2002; 11: 1119-1128 45 Lancaster E, Dalmau J. Neuronal autoantigens – pathogenesis, associated disorders and antibody testing. Nat Rev Neurol 2012; 8: 380-390 46 Radja GK, Cavanna AE. Treatment of VGKC complex antibody-associated limbic encephalitis: a systematic review. J Neuropsychiatry Clin Neurosci 2013; 25: 264-271 47 Vincent A, Buckley C, Schott JM et al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain 2004; 127: 701-712 48 Irani SR, Michell AW, Lang B et al. Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis. Ann Neurol 2011; 69: 892-900 49 Suokas K, Kampman O. Autoimmune encephalitis as a cause of psychosis. Duodecim 2014; 130: 469-474 50 Lai M, Hughes EG, Peng X et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol 2009; 65: 424-434 51 Höftberger R, Titulaer MJ, Sabater L et al. Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients. Neurology 2013; 81: 1500-1506 52 Carter J, Honnorat J. Autoimmune encephalopathies: expanding spectrum of GABAB receptor antibody disorders. Neurology 2013; 81: 1482-1483 53 Simonyi A, Schachtman TR, Christoffersen GRJ. Metabotropic glutamate receptor subtype 5 antagonism in learning and memory. Eur J Pharmacol 2010; 639: 17-25 54 Lancaster E, Martinez-Hernandez E, Titulaer MJ et al. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology 2011; 77: 1698-1701 55 Mat A, Adler H, Merwick A et al. Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF. Neurology 2013; 80: 1349-1350 56 Ali F, Rowley M, Jayakrishnan B et al. Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies. J Autoimmun 2011; 37: 79-87 57 Saiz A, Blanco Y, Sabater L et al. Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 2008; 131: 2553-2563 58 Solimena M, de Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci 1991; 14: 452-457 59 Geis C, Weishaupt A, Hallermann S et al. Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 2010; 133: 3166-3180 60 Szabo A, Dalmau J, Manley G et al. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. Cell 1991; 67: 325-333 61 Alamowitch S, Graus F, Uchuya M et al. Limbic encephalitis and small cell lung cancer. Clinical and immunological features. Brain 1997; 120: 923-928 62 Pignolet BS, Gebauer CM, Liblau RS. Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies: A beneficial antitumor immune response going awry. Oncoimmunology 2013; 2: e27384 63 Yu Z, Kryzer TJ, Griesmann GE et al. CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001; 49: 146-154 64 Key RG, Root JC. Anti-Yo mediated paraneoplastic cerebellar degeneration in the context of breast cancer: a case report and literature review. Psychooncology 2013; 22: 2152-2155 65 Endres D, Perlov E, Dersch R et al. Immunological findings in psychotic syndromes. Frontiers in Human Neuroscience 2015; [in submission] 66 Laadhar L, Sidhom O, Zitouni M et al. High Prevalence of antineuronal antibodies in Tunisian psychiatric inpatients. J Neuropsychiatry Clin Neurosci 2015; 27: 54-58 67 Leypoldt F, Buchert R, Kleiter I et al. Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease. J Neurol Neurosurg Psychiatr 2012; 83: 681-686 68 Friese MA, Magnus T. Antikörper-assoziierte autoimmune Enzephalopathien. In: Brandt T, Diener HC, Gerloff C. Therapie und Verlauf neurologischer Erkrankungen. Stuttgart: Kohlhammer; 2012 69 Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology 2011; 77: 179-189