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Am J Perinatol 2022; 29(14): 1563-1568
DOI: 10.1055/s-0041-1723829
Original Article

The Effect of a Short Course of Tocolytic Indomethacin on Urinary Biomarkers in Premature Infants

Ahmad El Samra 
1   Department of Pediatrics and Neonatology, Union Hospital, Terre Haute, Indiana
,
Ayesa Mian
2   Department of Pediatric Nephrology, University of Rochester, Rochester, New York
,
Marc Lande
2   Department of Pediatric Nephrology, University of Rochester, Rochester, New York
,
Hongyue Wang
3   Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York
,
Ronnie Guillet
4   Department of Pediatrics and Neonatology, University of Rochester, Rochester, New York
› Institutsangaben Funding The study was supported by a generous grant from the Gerber Foundation and the Bradford fellowship research award at University of Rochester, NY.
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Abstract

Objective The aim of this study was to determine the effects of a 2-day prenatal course of indomethacin on the premature kidney as reflected by serum creatinine and urinary biomarkers.

Study Design Urine of infants ≤32 weeks was collected for the first 14 days and analyzed for cystatin C, neutrophil gelatinase-associated lipocalin, osteopontin, β2 microglobulin, epidermal growth factor, uromodulin, and microalbumin. Bivariate analysis compared serum creatinine and biomarkers of exposed (INDO) and unexposed (CONT) subjects.

Results Fifty-seven infants (35 CONT and 22 INDO) were studied. The cohorts were similar in gestational age, birthweight, race, gender, nephrotoxic medication exposure, and Apgar's scores. CONT had more dopamine exposure and included more pre-eclamptic mothers (p = 0.005). No difference in creatinine-based acute kidney injury or the log transformed mean, maximum, and minimum values of urinary biomarkers was detected.

Conclusion Our findings suggest that a short course of tocolytic indomethacin does not result in neonatal acute kidney injury.

Key Points

  • A short prenatal course of indomethacin does not result in neonatal acute kidney injury (AKI).

  • Urinary EGF might have a promising role as a more sensitive biomarker for early detection of AKI in premature infants.

Keywords

acute kidney injury - prematurity - biomarkers - indomethacin


Publikationsverlauf

Eingereicht: 03. August 2020

Angenommen: 05. Januar 2021

Artikel online veröffentlicht:
16. Februar 2021

© 2021. Thieme. All rights reserved.

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