White light Endoscopy Versus Magnification Endoscopy with Optical Enhancement for the Evaluation Of H.Pylori Gastric Mucosal Changes and Atrophic Gastritis: a Randomized Trial

Aims We aimed to compare white light endoscopy versus magnification endoscopy with an optical enhancement for the evaluation of H. pylori gastric mucosal changes and atrophic gastritis.

Methods A single-center, cross-over diagnostic trial. Consecutive patients complaining of dyspepsia (March/2020-Oct/2020) were submitted for a white light EGD and then to a magnification endoscopy with optical enhancement (MEOE) by another independent operator. Gastric mucosa was evaluated using a standardized protocol and biopsies were taken following Sydney guidelines. The final diagnosis was based on histopathology results.

Results 149 patients were included; the median age was 50 years and 67.51 % of patients were female. 125/149 of patients had non-atrophic gastritis in comparison to 12/149 who had chronic atrophic gastritis. White light endoscopic had a sensitivity, specificity, PPV, NPV, and agreement of 67 %, 96 %, 62 %, 97 %, and 94 % for defining chronic atrophic gastritis; similar to magnification endoscopy with optical enhancement that had a sensitivity, specificity, PPV, NPV and agreement of 58 %, 91 %, 37 %, 96 % 89 %, respectively. Regarding H. pylori infection, white light endoscopy had a sensitivity, specificity, PPV, NPV, and agreement of 72 %, 43 %, 36 %, 77 %, 52 %, respectively; similar to magnification endoscopy with optical enhancement that had a sensitivity, specificity, PPV, NPV and agreement of 80 %, 39 %, 37 %, 82 %, 82 %, 52 %.

Conclusions There is no significant difference between white light endoscopy and magnification endoscopy with optical magnification for defining normal gastric mucosa, chronic atrophic gastritis, and H. pylori infection in patients with dyspepsia. Larger, multicenter trials with more participants are necessary to validate these results.

Citation: Robles-Medranda C, Oleas R, Alcivar-Vasquez J P et al. OP52 WHITE LIGHT ENDOSCOPY VERSUS MAGNIFICATION ENDOSCOPY WITH OPTICAL ENHANCEMENT FOR THE EVALUATION OF H.PYLORI GASTRIC MUCOSAL CHANGES AND ATROPHIC GASTRITIS: A RANDOMIZED TRIAL. Endoscopy 2021; 53: S23.

Publication History

Article published online:
19 March 2021