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DOI: 10.1055/s-0041-1724386
Does Endorings Improve the Adenoma Detection Rate at Colonoscopy? A Meta-Analysis Of Data from Individual Patients in Randomized Controlled Trials
Aims Data on the impact of the EndoRings device on adenoma detection at colonoscopy is conflicting. The aim of this meta-analysis was to analyze individual patient based data from all the published trials to assess whether EndoRings improves the detection of colorectal adenomas.
Methods We searched MEDLINE/PubMed, Scopus and Scholar databases through May 2020 for randomized controlled trials that assessed detection of colorectal polyps by EndoRings vs. standard colonoscopy. We included studies whose authors provided data on individual patients. The primary outcome was adenoma detection rate (ADR). Patients with inadequate colon cleansing were excluded. A two-stage random-effect meta-analysis was applied to obtain pooled estimates as odds ratio (OR) and mean difference (MD) along with 95 % confidence interval (CI).
Results 5 studies published up to 2020, comprising 2,371 patients and 3,023 detected adenomas were included for quantitative synthesis. The ADR was slightly higher for EndoRingsTM arm vs. standard colonoscopy (637/1,188, 53.6 % vs. 581/1,183, 49.1 %; OR 1.21, CI 1.01-1.44). No significant difference was found when examining advanced ADR (297/1,188, 25 % vs. 284/1,183, 24 %; OR 1.08, CI 0.84-1.38), adenomas per colonoscopy (1,562/1,188 vs. 1,461/1,183; MD 0.11, CI -0.27 to 0.49), advanced adenomas per colonoscopy (194/1,188 vs. 225/1,183; MD -0.01, CI -0.12 to 0.10), right colon ADR (450/1,188, 37.9 % vs. 414/1,183, 35 %; OR 1.17, CI 0.93-1.49), right colon advanced ADR (63/1,188, 5.3 % vs. 72/1,183, 6.1 %; OR 0.91, CI 0.57-1.45), adenomas per colonoscopy in the right colon (808/1,188 vs. 719/1,183; MD 0.11, CI -0.12 to 0.33) and advanced adenomas per colonoscopy in the right colon (78/1,188 vs. 97/1,183; MD -0.01, CI -0.07 to 0.07).
Conclusions EndoRings marginally improves the detection of adenomas during colonoscopy, but not that of advanced adenomas nor other colonoscopy quality parameters. The clinical relevance of this add-on device is uncertain.
Citation: Frazzoni L, Thayalasekaran S, Hassan C et al. OP128 DOES ENDORINGS IMPROVE THE ADENOMA DETECTION RATE AT COLONOSCOPY? A META-ANALYSIS OF DATA FROM INDIVIDUAL PATIENTS IN RANDOMIZED CONTROLLED TRIALS. Endoscopy 2021; 53: S53.
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Publikationsverlauf
Artikel online veröffentlicht:
19. März 2021
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