Diagnostic Accuracy Of Applying The Wasp Classification To Blue Light Imaging And Linked Color Imaging For Real-Time Colorectal Polyp Charaterisation

BBSL Houwen; JLA Vleugels; M Pellisé; L Rivero-Sánchez; F Balaguer; R Bisschops; S Tejpar; A Repici; D Ramsoekh; MAJM Jacobs; RM Schreuder; MF Kamiński; M Rupińska; P Bhandari; MGH van Oijen; L Koens; BAJ Bastiaansen; KMAJ Tytgat; P Fockens; E Dekker; Y Hazewinkel

doi:10.1055/s-0041-1724443

Endoscopy, Table of Contents

Endoscopy 2021; 53(S 01): S77
DOI: 10.1055/s-0041-1724443

Abstracts | ESGE Days

ESGE Days 2021 Oral presentations

Saturday, 27 March 2021 11:00 – 11:45 Resect and discard for diminutive polyps: Where do we stand? Room 6

Diagnostic Accuracy Of Applying The Wasp Classification To Blue Light Imaging And Linked Color Imaging For Real-Time Colorectal Polyp Charaterisation

BBSL Houwen

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

JLA Vleugels

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

M Pellisé

²Department of Gastroenterology, Hospital Clinic of Barcelona, Barcelona, Spain

³Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

,

L Rivero-Sánchez

²Department of Gastroenterology, Hospital Clinic of Barcelona, Barcelona, Spain

³Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

,

F Balaguer

²Department of Gastroenterology, Hospital Clinic of Barcelona, Barcelona, Spain

³Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain

,

R Bisschops

⁴Department of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium

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S Tejpar

⁴Department of Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium

,

A Repici

⁵Department of Gastroenterology and Hepatology, Instituto Clinico Humanitas, Milan, Italy

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D Ramsoekh

⁶Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location VU University Medical Centre, VU University Amsterdam, Amsterdam, Netherlands

,

MAJM Jacobs

⁶Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location VU University Medical Centre, VU University Amsterdam, Amsterdam, Netherlands

,

RM Schreuder

⁷Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, Netherlands

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MF Kamiński

⁸Department of Cancer Prevention, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

⁹Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, Warsaw, Poland

,

M Rupińska

⁸Department of Cancer Prevention, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland

⁹Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Centre for Postgraduate Education, Warsaw, Poland

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P Bhandari

¹⁰Department of Gastroenterology, Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom

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MGH van Oijen

¹¹Department of Medical Oncology, Amsterdam University Medical Centre, Cancer Centre Amsterdam, University of Amsterdam, Amsterdam, Netherlands

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L Koens

¹²Department of Pathology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

BAJ Bastiaansen

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

KMAJ Tytgat

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

P Fockens

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

E Dekker

¹Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands

,

Y Hazewinkel

¹³Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Radboud University of Nijmegen, Nijmegen, Netherlands

› Author Affiliations

Abstract

Full Text

Aims The Workgroup SerrAted polypS and Polyposis (WASP) classification for endoscopic characterisation of colorectal polyps has been validated using Narrow Band imaging (NBI) technology, leaving uncertainty regarding its applicability to other imaging techniques. The aim of this study was to address the diagnostic accuracy of real-time polyp characterisation applying the WASP classification to Blue Light imaging (BLI), Linked Color imaging (LCI) and high-definition white light endoscopy (HD-WE).

Methods This is a post-hoc analysis of a prospective study in which 22 experienced endoscopists (>2,000 colonoscopies) from eight international centres participated. Lesions were characterised using the WASP classification, including a high- or low-confidence statement. Endoscopists were familiar with the WASP classification, but were not formally trained for the purpose of this study. Endoscopists could use LCI, BLI and HD-WLE to assess each lesion. Histopathology was reference standard. For the calculation of the diagnostic accuracies adenomas, sessile serrated lesions and hyperplastic polyps were considered different histological subtypes.

Results In 332 patients, 341 lesions were detected. For the analysis, 269 histologically confirmed adenomas (n = 165), sessile serrated lesions (n = 27) and hyperplastic polyps (n = 77) were included for which an optical diagnosis was recorded. Polyp characterisation was performed with high confidence in 82.9 %. The overall accuracy for polyp characterisation was 75.1 % (95 % confidence interval [CI] 69.5-80.1 %), which was 78.0 % (95 % confidence interval [CI] 72.0-83.2 %) for high confidence assignments only. Adenomas were characterised with 80.0 % (95 % CI 73.1-85.8 %) accuracy and increased to 84.9 % (95 % CI 77.8-90.4 %) for high-confidence predictions. The accuracy for diminutive polyp characterisation was 74.7 % (95 % CI 68.4-80.3 %), compared with an accuracy of 78.2 % (95 % CI 71.4-84.0 %) for high-confidence assignments.

Conclusions This is the first study to determine diagnostic accuracies for colorectal polyp characterisation, when performed by expert endoscopists using the WASP classification with BLI, LCI and HD-WLE (NCT03344289).

Citation: Houwen BBSL, Vleugels JLA, Pellisé M et al. OP186 DIAGNOSTIC ACCURACY OF APPLYING THE WASP CLASSIFICATION TO BLUE LIGHT IMAGING AND LINKED COLOR IMAGING FOR REAL-TIME COLORECTAL POLYP CHARATERISATION. Endoscopy 2021; 53: S77.