The Prediction Of Inadequate Colon Capsule Cleansing: A Cohort Selection Guided By CC-Clear

Aims Introduction In order to optimize the rate of adequate cleansing in colon capsule, it may be important to identify risk factors that can predict a sub-optimal colon preparation.

Aim To define predictive factors for inadequate bowel preparation in colon capsule, according to CC-CLEAR (Colon Capsule CLEansing Assessment and Report).

Methods Retrospective, single centre, cohort study. Patients’ demographics, data, and quality of bowel preparation, according to CC-CLEAR, were collected retrospectively. A univariate analysis tested the association between covariables and the outcome, inadequate cleansing. The statistically significant variables were included in multivariable logistic binary regression and a ROC assessment was performed.

Results We included 133 consecutive colon capsules, from 2015 to 2020. Seventy-two percent were female, with a mean age of 65 years. The main indication for colon capsule was incomplete colonoscopy, in 94 % of the cases. The colon capsules cleansing was graded as good or excellent in 53 % of patients according to CC-CLEAR. Several variables presented statistical significance with an inadequate cleansing in the univariate analysis. The variables previous inadequate cleansing (OR 74.6 [11.70-475.77] p<0.001]), chronic laxative (OR 35.72 [3.06-417.61] p=0.004]), chronic antidepressant (OR 8.664 [2.08-36.03] p=0.003]) and impaired mobility (OR 16.09 [1.89-136.91] p=0.01]) were independently associated with the outcome inadequate cleansing, after adjusting for confoundment. The multivariate model including these variables displayed an excellent discriminative power (AUC ROC curve 0.954 [0.915-0.992] p < 0.001).

Conclusions A previous inadequate cleansing, the use of chronic laxative and chronic antidepressant, and an impaired mobility are predictors of inadequate colon capsule cleansing, according to CC-CLEAR. These 4 predictors come together as a model enabling an accurate categorization of the patients at major risk, with an excellent discriminative power and performance, which seems essential in the selection of patients for optimization of the colon cleansing protocol.

Citation de Sousa Magalhães R, Boal Carvalho P, Rosa B et al. eP128 THE PREDICTION OF INADEQUATE COLON CAPSULE CLEANSING: A COHORT SELECTION GUIDED BY CC-CLEAR. Endoscopy 2021; 53: S138.

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Artikel online veröffentlicht:
19. März 2021