Endoscopic Ultrasound Share-Wave Elastography Of The Right And Left Hepatic Lobe Predicts Liver Cirrhosis: A Diagnostic Trial

Aims We aim to evaluate endoscopic ultrasound share-wave elastography of the liver to predict liver cirrhosis.

Methods A single-center, diagnostic cohort study. Consecutive patients with history of chronic liver disease were evaluated with a EUS share wave elastography of the right and left hepatic lobes. Patients without a history of any medical condition despite subepithelial lesions were included as control. A transient elastography measurement of the liver was performed in both study and control patients in order to evaluate for correlation between elastography measurements. We calculated the overall accuracy of EUS- share wave elastography of the liver in the prediction of liver cirrhosis. Statistical analysis was performed on R v.3.6.0.

Results Among the 28 patients included, 14 had cirrhosis of the liver. The median age was 65.5 years, 64.3 % were female. 92.9 % of cirrhotic cases had a Child-Pugh A. The EUS share-wave elastography of the right hepatic lobe has a direct, proportional, and significant correlation (r=0.693 [95 % CI 0.431 – 0.847; p < 0.001]) as well as with the EUS share-wave of the left hepatic lobe (r=0.460 [95 % CI 0.105 – 0.711; p = 0.014]). The EUS-share wave of the right and left hepatic lobe reached an area under the receiver operating characteristics curve (AUROC) of 0.98 and 0.96, respectively. For identification of patients with cirrhosis, the EUS share-wave elastography of the right hepatic lobe with a cut-off value of ≥10.7 kPa had a sensitivity, specificity, PPV, and NPV of 100 %, 93 %, 93 %, 100 %, respectively. In the left hepatic lobe using a cut-off value of ≥14.0 kPa, EUS-share wave had a sensitivity, specificity, PPV, and NPV of 93 %, 93 %, 93 %, 93 %, respectively.

Conclusions EUS-share wave of the liver accurately diagnoses patients with liver cirrhosis. EUS-share wave of the right and left hepatic lobe correlates with transient elastography measurements of the liver. Larger studies are necessary to validate these data.

Citation Robles-Medranda C, Oleas R, Del Valle R et al. eP451 ENDOSCOPIC ULTRASOUND SHARE-WAVE ELASTOGRAPHY OF THE RIGHT AND LEFT HEPATIC LOBE PREDICTS LIVER CIRRHOSIS: A DIAGNOSTIC TRIAL. Endoscopy 2021; 53: S245.

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Artikel online veröffentlicht:
19. März 2021