Analysis of tumor progression of laryngeal dysplasia based on the degree of dysplasia

In 2017, the World Health Organization (WHO) proposed a two-stage system for describing laryngeal dysplasia. A distinction is made between "low grade" and "high grade" dysplasia. In Germany a classification of laryngeal dysplasia is made by distinguishing between low-, medium- and high-grade dysplasia. As a rule, only patients with high-grade dysplasia undergo further surgical interventions. The aim of the study was the retrospective evaluation of tumor progression depending on the degree of dysplasia at the ENT University Hospital Würzburg.

A total number of 393 patients were enrolled in the study. Histological confirmation was obtained by biopsy using microlaryngoscopy. Depending on the histopathological diagnosis the progression to carcinoma in follow-up was evaluated.

Histopathological evaluation of obtained tissue revealed hyper- or parakeratosis without dysplasia in 253 cases, low-grade dysplasia in 56 cases, medium-grade dysplasia in 39 cases, high-grade dysplasia in 45 cases. The rate of progression to carcinoma in follow-up was similarly high in the groups of medium-grade (41 % ), high-grade dysplasia (48 % ). In the groups hyper- and parakeratosis without dysplasia (5 % ) and low-grade dysplasia (8 % ) the progression rate was significantly lower.

The current study underlines the importance of the new WHO classification. In our collective, medium-grade dysplasia showed a comparatively more aggressive disease progression similar to high-grade dysplasia.

Poster-PDF A-1576.pdf

Conflict of interest

Der Erstautor gibt keinen Interessenskonflikt an.

Publication History

Article published online:
13 May 2021