CC BY-NC-ND 4.0 · Laryngorhinootologie 2021; 100(S 02): S121-S122
DOI: 10.1055/s-0041-1727961
Abstracts
Head-Neck-Oncology: HPV / Tumor Marker

Analysis of Human papillomavirus (HPV) 16 early protein antibodies and follow-up of HPV-16 E6-positive patients in the prospective cohort of the Hamburg City Health Study (HCHS)

B Becker
1   Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Hamburg
,
C-J Busch
1   Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Hamburg
,
AS Hoffmann
1   Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Hamburg
,
T Rieckmann
1   Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Hamburg
,
N Brenner
3   Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie, Heidelberg
,
C Betz
1   Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Hamburg
,
A Jagodzinski
4   Universitätsklinikum Hamburg Eppendorf, Epidemiologisches Studienzentrum, Hamburg City Health Study, Hamburg
,
L Schröder
3   Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie, Heidelberg
,
M Pawlita
3   Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie, Heidelberg
,
D Viarisio
3   Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie, Heidelberg
,
T Waterboer
3   Deutsches Krebsforschungszentrum (DKFZ), Infektionen und Krebs-Epidemiologie, Heidelberg
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    Introduction The incidence of oropharyngeal cancer attributable to human papillomaviruses (HPV-OPC) has been rising constantly over the last decades. How oral HPV infections progress into cancer is poorly understood due to the lack of detectable precancerous lesions, making early detection of HPV-OPC difficult. Antibodies to HPV16 early proteins, especially E6, are strongly associated with incident but also prospective HPV-OPSCC. Within a prospective epidemiological cohort, we analyzed HPV16 serum antibodies to identify patients at high risk for HPV-driven OPC.

    Patients and Methods The study is embedded within the Hamburg City Health Study (HCHS), a single center, prospective, epidemiologic cohort study that started enrolling 45.000 participants (45-74 years) in 2015. We analyzed HPV16 serum antibodies to identify individuals at high risk for HPV-OPC. The first 4,460 participants’ sera were screened for HPV16 E6, E1, E2 and E7 antibodies using multiplex serology.

    Results Of these participants, 36 (0.8 % ) were HPV16 E6 seropositive including 12 (0.3 % ) seropositive for at least one additional HPV16 early protein. These individuals were considered at high risk for HPV-OPC, and re-contacted for head and neck examination. Until now, 3 of the 12 participants were identified with asymptomatic HPV-OPC in our follow-up. Of the remaining 9 individuals with high-risk HPV-OPC antibody profile, 7 were free of detectable symptoms and undergo regular follow-up every 6 months. 2 other individuals were lost to follow-up.

    Conclusion Detection of HPV16 early antibodies might be an innovative method to identify asymptomatic HPV-OPC patients at an early stage, and may reduce morbidity and improve survival.

    Poster-PDF A-1625.pdf


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    Conflict of interest

    Der Erstautor gibt keinen Interessenskonflikt an.

    Address for correspondence

    Dr. med. Becker Benjamin
    Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde
    Hamburg

    Publication History

    Article published online:
    13 May 2021

    © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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