CC BY-NC-ND 4.0 · Laryngorhinootologie 2021; 100(S 02): S237
DOI: 10.1055/s-0041-1728493
Abstracts
Otology / Neurotology / Audiology

Thermal Injury to the Facial Nerve Conduction in a Rabbit Model

Y Zhao
1   Peking Union Medical College Hospital, ENT Department Beijing China
,
C Zhu
1   Peking Union Medical College Hospital, ENT Department Beijing China
,
G Feng
1   Peking Union Medical College Hospital, ENT Department Beijing China
,
Z Gao
1   Peking Union Medical College Hospital, ENT Department Beijing China
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    Abstract

    Objective To reduce the risk of thermal injury to the facial nerve, this study aimed at determining the thermal thresholds for facial nerve damage using continuous intraoperative neuromonitoring in rabbit models.

    Methods Eight rabbits weighing 2.8 to 3.3 kg with 16 facial sides were used for this study. We applied automatic periodic stimulation (APS) to the dissected upper buccal branch of facial nerve. We first filled the experimental tube with water continuously, which rapidly rose from room temperature till loss of signal on electromyography monitoring device. We then analyzed temperature susceptibility of facial nerve under different thermal dose by comparing the iso-effect of cumulative equivalent minutes at 43 °C (CEM43°C. The segment of injured facial nerve underwent pathological examination immediately after surgery and three days later.

    Results We witnessed a temporary increase of amplitude around 37-42°C, and immediately began to decrease afterwards. Loss of signal was observed at temperature above 58°C. After 64 min(CEM43°C) and 128 min(CEM43°C) of continuous irrigation, evoked potential was found lower in the 128 min (CEM43°C) group, which recovered only to about 60 % . Pathological examination revealed more severe lesion 3 days after thermal damage.

    Conclusion Continuous intraoperative neuromonitoring can be used as a tool to detect nerve damage. The facial nerve function may continue to deteriorate after thermal injury.

    Poster-PDF A-1557.pdf

    This study was supported by the Natural Science Foundation of Beijing (Grant No. 7194309) and National Key Research and Development Project (2019YFB1311801).


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    Conflict of interest

    Der Erstautor gibt keinen Interessenskonflikt an.

    Address for correspondence

    Dr.med. Gao Zhiqiang
    Peking Union Medical College Hospital, ENT Department
    Beijing
    China   

    Publikationsverlauf

    Artikel online veröffentlicht:
    13. Mai 2021

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