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Journal of Pediatric Neurology 2022; 20(01): 075-079
DOI: 10.1055/s-0041-1728776
Case Report

Acute Disseminated Encephalomyelitis Following Campylobacter jejuni Infection in a 12-Year-Old Girl

Ingrid Yolanda Camelo 
1   Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Massachusetts School of Medicine, Baystate Medical Center, Springfield, Massachusetts, United States
,
Mandeep Rana
2   Division of Pediatric Neurology, Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, United States
,
Ellen Rae Cooper
3   Division of Pediatric Infectious Diseases, Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, United States
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Abstract

We reported a case of acute disseminated encephalomyelitis (ADEM) in a 12-year-old girl shortly after developing fever and vomiting, and ultimately found to have Campylobacter jejuni by antigen detection and conventional stool culture. Campylobacter jejuni has been associated with peripheral demyelinating diseases including Guillain–Barre's syndrome, but it has not been previously implicated in central demyelination in children. The clinical description and review of the literature are included here.

Keywords

Campylobacter - ADEM - pediatric


Publication History

Received: 13 January 2021

Accepted: 08 March 2021

Article published online:
01 June 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Tenembaum S, Chitnis T, Ness J, Hahn JS. International Pediatric MS Study Group. Acute disseminated encephalomyelitis. Neurology 2007; 68 (16, Suppl 2): S23-S36
    CrossrefPubMedGoogle Scholar
  • 2 Yu RK, Usuki S, Ariga T. Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases. Infect Immun 2006; 74 (12) 6517-6527
    CrossrefPubMedGoogle Scholar
  • 3 Ryan MM. Guillain-Barré syndrome in childhood. J Paediatr Child Health 2005; 41 (5-6): 237-241
    CrossrefPubMedGoogle Scholar
  • 4 Esposito S, Di Pietro GM, Madini B, Mastrolia MV, Rigante D. A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children. Autoimmun Rev 2015; 14 (10) 923-929
    CrossrefPubMedGoogle Scholar
  • 5 Nachamkin I, Arzarte Barbosa P, Ung H. et al. Patterns of Guillain-Barre syndrome in children: results from a Mexican population. Neurology 2007; 69 (17) 1665-1671
    CrossrefPubMedGoogle Scholar
  • 6 Nasralla CA, Pay N, Goodpasture HC, Lin JJ, Svoboda WB. Postinfectious encephalopathy in a child following Campylobacter jejuni enteritis. Am J Neuroradiol 1993; 14 (02) 444-448
    PubMedGoogle Scholar
  • 7 McLeod SA, Wee W, Jacob FD, Chapados I, Bolduc FV. Recurrent diplopia in a pediatric patient with Bickerstaff brainstem encephalitis. Case Rep Neurol Med 2016; 2016 (1–4): 5240274
    PubMedGoogle Scholar
  • 8 Tsugawa T, Nikaido K, Doi T. et al. Guillain-Barre syndrome with meningoencephalitis after Campylobacter jejuni infection. Pediatr Infect Dis J 2004; 23 (10) 966-968
    CrossrefPubMedGoogle Scholar
  • 9 Mohammed RR, Jan MM. Co-morbid Guillain-Barré syndrome and acute disseminated encephalomyelitis. Neurosciences (Riyadh) 2013; 18 (02) 166-168
    PubMedGoogle Scholar
  • 10 Marziali S, Picchi E, Di Giuliano F. et al. Acute disseminated encephalomyelitis following Campylobacter jejuni gastroenteritis: case report and review of the literature. Neuroradiol J 2017; 30 (01) 65-70
    CrossrefPubMedGoogle Scholar