CC BY-NC-ND 4.0 · Laryngorhinootologie 2021; 100(S 02): S285
DOI: 10.1055/s-0041-1728860
Abstracts
Rhinology: Mucous membrane

Classification of endonasal hereditary haemorrhagic telangiectasia using digital microscopy

F Kashani
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
,
A Schneider
2   Munich Surgical Imaging, München
,
H Schinke
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
,
M Bertlich
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
,
BG. Weiß
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
,
M Canis
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
,
F Haubner
1   Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München, München
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    Background Recurrent spontaneous epistaxis is the most common clinical manifestation in hereditary haemorrhagic telangiectasia (HHT) patients. There is no standard classification for the endonasal manifestations of HHT. The aim of the present study was to propose a clinical classification of endonasal HHT lesions using digital microscopy. Furthermore, we investigated the correlation between VEGF (vascular endothelial growth factor) plasma levels and clinical manifestations of HHT, which had previously only been investigated in one study.

    Methodology/Principal In a retrospective study we classified endonasal Teleangiectasias in 28 HHT patients according to their 3D morphology using a fully digital high-resolution surgical microscope (ARRISCOPE). We investigated the correlation between the severity classes of endonasal manifestation and a) severity of epistaxis, evaluated by epistaxis severity score (ESS), b) quality of life, assessed by visual analogue scale (VAS), c) Haemoglobin and d) plasma VEGF level.

    Results Severity of epistaxis tended to increase with severity of endonasal manifestation. Quality of life showed a negative correlation with the severity of endonasal manifestations. A moderate positive correlation was found between plasma VEGF level and severity of endonasal manifestation. HHT patients with extranasal manifestations presented a tendentially higher plasma VEGF level.

    Conclusions A standardized classification for endonasal manifestation of HHT using digital microscopy reflecting the severity of symptoms can assists in the evaluation of the efficacy of various treatment modalities in different endonasal severity classes. These warrant further investigation in larger prospective studies.

    Poster-PDF A-1614.pdf

    Die Deutsche Forschungsgesellschaft (“Digitales Operationsmikroskop” INST 409/219-1 FUGG).


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    Conflict of interest

    Der Erstautor gibt keinen Interessenskonflikt an.

    Address for correspondence

    Dr. med. Kashani Fatemeh
    Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde des Klinikums der Universität München
    München

    Publication History

    Article published online:
    13 May 2021

    © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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