CC BY-NC-ND 4.0 · Laryngorhinootologie 2021; 100(S 02): S314
DOI: 10.1055/s-0041-1728954
Abstracts
Tissue Engineering / Stem Cells

Olfactory stem cells - a promising autologous approach to cell based therapies

S Volkenstein
1   Klini für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Hals-Chirurgie der Ruhr Universität Bochum, St. Elisabeth-Hopsital, Bochum
,
C Sengstock
2   Chirurgische Klinik und Poliklinik, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Chirurgische Forschung, Bochum
,
M Rövekamp
2   Chirurgische Klinik und Poliklinik, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Chirurgische Forschung, Bochum
,
S Dazert
1   Klini für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Hals-Chirurgie der Ruhr Universität Bochum, St. Elisabeth-Hopsital, Bochum
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    Background Regerative therapeutic approaches may be a promising tool especially in neurodegenerative diesease. There is a variety of stem stell sources in humans, having each advantages as well as disadvantages. The utilization of autologous human olfactory stem- and precursor cells is a minimal invasive method to gain cells for different therapeutical approaches not limited to ENT-realated dieseas.

    Metrhods We harvested olfactory and respiratory mucosa probes in more than 20 patients having a septumplasty after getting their informed consent. We purified olfactory stem cells and characterized these before differentiation.

    Results We did not observe any complications while or after harvesting the mucosa probes in patients. In contrast to respiratory mucosa, we could isolate olfactory stem cells in our olfactory mucosa probes. We were able to proliferate and differentiate these into neuronal-like cells afterwards.

    Conclusion The utilisation of olfactory stem cells may be a prospective autologous therapeutic approach for the treatment of different neuroregenrative diesease.

    Poster-PDF A-1543.pdf


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    Conflict of interest

    Der Erstautor gibt keinen Interessenskonflikt an.

    Address for correspondence

    Volkenstein Stefan
    Klini für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Hals-Chirurgie der Ruhr Universität Bochum, St. Elisabeth-Hopsital
    Bochum

    Publication History

    Article published online:
    13 May 2021

    © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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