Comparison of the Efficacy of Septoplasty with Nonsurgical Management in Improving Nasal Obstruction in Patients with Deviated Nasal Septum – A Randomized Clinical Trial

Abstract

Introduction In the current era, the major indication for septoplasty is nasal obstruction due to deviated nasal septum (DNS). Even though septoplasty is a commonly performed surgery, its effectiveness in relieving nasal obstruction in DNS has not been proven.

Objective The present study involved the measurement of both objective (nasal patency) and subjective (quality of life measures) outcome measures for the evaluation of the efficacy of septoplasty as compared with medical management.

Methods Patients with DNS presenting with nasal obstruction were included and randomized into a septoplasty group or into a nonsurgical management group, with 70 patients in each group. The improvement in nasal obstruction was assessed subjectively by the visual analogue scale (VAS), and the sino-nasal outcome test-22 (SNOT-22) and the nasal obstruction symptom evaluation (NOSE) questionnaires and was measured objectively by assessment of nasal patency by peak nasal inspiratory flow (PNIF) at 0, 1, 3, and 6 months of treatment in both groups.

Results The average VAS, SNOT-22 and NOSE scores for the septoplasty versus the nonsurgical group before treatment were 6.28 versus 6.0, 19.5 versus 15, and 14 versus 12, respectively, and at 6 months post-treatment, the scores were 2.9 versus 5.26, 10 versus 12, and 8 versus 10 (p = 0.001), respectively. The average PNIF scores at 0 and 6 months were 60/50 l/min and 70/60 l/min, respectively, in the septoplasty group (p = 0.001); the scores at 0 and 6 months in the nonsurgical management group were 60/60 l/min and 70/70 l/min, respectively (p = 0.001).

Conclusion Surgical correction of DNS by septoplasty improves nasal obstruction better than nonsurgical management at 6 months postsurgery.

Keywords

visual analogue scale - PNIF - SNOT-22 - NOSE score - intranasal corticosteroids - topical decongestants

Introduction

Deviated nasal septum (DNS) is a widespread clinical condition that affects up to 80% of the population, as shown in various studies.[1] It is characterized by displacement of the nasal septum, which normally divides the nasal cavity into right and left nasal passages. Although it is asymptomatic in the majority of patients, the most common and troublesome symptom of DNS is nasal obstruction.

Surgical correction of DNS by septoplasty is one of the most common otorhinolaryngology surgeries in adults.[2] In the current era, the major indication for septoplasty is nasal obstruction and other associated symptoms of DNS. Although septoplasty is a commonly performed surgery, its effectiveness in relieving nasal obstruction in adults with DNS has not been proven and remains indecisive. Scientific evidence from the literature on the benefits of septoplasty are not well-described.[3]

Many studies have revealed that septoplasty improves health-related quality of life significantly in the postoperative period.[4] The risk of bias is high, since all available evidence in the literature are based on studies that are only observational in nature, and randomized clinical trials are lacking. The beneficial effects could also be explained by additional factors like the course of the disease or additional interventions such as turbinate reduction or conchoplasty performed in these patients. The biases mentioned above make the advocated benefits of septoplasty questionable and possibly exaggerated.

The present study involves the measurement of both objective (nasal patency) and subjective (quality of life measures) outcome measures for the evaluation of the efficacy of septoplasty, and it is compared with medical management for ameliorating nasal obstruction in patients with DNS. The lack of evidence of the effectiveness of septoplasty explains the need for the present randomized clinical trial.

The aim of the present study was to assess and compare the efficacy of septoplasty with nonsurgical management in improving nasal obstruction in patients with DNS by both subjective and objective measures. The subjective assessment was done by the visual analogue scale (VAS), the nasal obstruction symptom evaluation (NOSE) scale and the sino-nasal outcome test-22 (SNOT-22) scores, and the objective assessment was done by peak nasal inspiratory flow (PNIF).[5]

Materials and Methods

Study Design

The present study was a randomized clinical trial conducted during the period from February 2017 to December 2018. Informed consent was taken from all the patients who participated in the study. Approval from the Institute Research Council and Ethics Committee (JIP/IEC/2016/1061) was obtained. All provisions of the Declaration of Helsinki were followed. Patients > 18 years old with nasal obstruction due to DNS were included. Patients with prior septal surgeries, septoplasty done for indications other than DNS, and those with a strong preference to surgery were excluded from the study. With a 5% level of significance and 90% power, the sample size was calculated to be 70 in each group for an expected dropout rate of 20%.

Once the diagnosis of DNS was made based on the history of nasal obstruction, clinically by anterior rhinoscopy, and confirmed by diagnostic nasal endoscopy, the patients were randomized into either the septoplasty or the nonsurgical management group by the opaque envelope method.

Nasal patency was assessed at the time of enrollment into the study and at intervals of 1, 3, and 6 months after treatment, subjectively by VAS, SNOT-22, and NOSE score, and objectively by PNIF measurement in both groups.

The VAS scale ranges from 0 to 10; with 0 signifying the least severe and 10 the most severe nasal obstruction. In SNOT-22, problems are rated over the past 2 weeks, and each symptom is rated based on its severity. In the NOSE scale, 5 symptoms are considered, and severity is graded from 0 to 4, with 0 being ‘not a problem’ and 4 being ‘severe problem’. The answers were added and multiplied by 5 to base the scale out of a possible score of 100 points for analysis.

Peak nasal inspiratory flow measures inspiratory flow through the nasal passage. The patients were asked to exhale fully, hold the flow meter horizontally, were ensured that the facemask formed an airtight seal around the nose and inhaled forcibly through the nose. The procedure was done in one nostril at a time by blocking the other. The peak nasal inspiratory maneuver should be a short, sharp, inspiratory action of a duration of ∼ 1 second ([Fig. 1]). The peak nasal inspiratory test was repeated three times, and the highest result was taken into account. The mask was disinfected between patients to avoid cross-infection.

Fig. 1 Patient performing peak nasal inspiratory flow (PNIF) assessment using a PNIF meter.

The patients of the septoplasty group were put under sedation, and the procedure was performed under local anesthesia using aseptic precautions. A hemi-transfixion incision was made on the caudal end of the septum and extending from the floor of the vestibule to the dorsum of the columella. Following the incision, mucoperichondrial flaps were elevated from the quadrilateral cartilage until the bony cartilaginous junction using a Freer elevator, and an anterior and inferior tunnel were created connecting them. The cartilaginous incision was made anteriorly, and flap elevation and exposure was performed on the contralateral side. The inferior strip of cartilage was removed along the maxillary crest, and at least 1 cm of the caudal end of the septum was preserved to maintain support of the nasal tip.

Deviated portions of septum were removed, preserving nondeviated parts and a dorsal and a caudal strut to maintain support of the dorsum. Bilateral nasal cavities were packed with merocel or with an antibiotic-antiseptic coated pack to achieve hemostasis. The patients were kept reclined on a couch with 30° of head end elevation to reduce venous congestion in the septum and reduce bleeding. The pack was removed within 48 hours, and the patients were discharged on a weeklong course of antibiotics and analgesics.

The nonsurgical management group underwent subjective as well as objective assessments of nasal patency as soon as the diagnosis was established and were started on nonsurgical measures like topical nasal decongestants (1% ephedrine drops) for 1 week during each follow-up visit and topical nasal corticosteroid sprays (50 mcg of fluticasone nasal spray – 1 spray in each nostril administered twice daily up to a total dose of 200 mcg/day for 6 months). Patients in both groups were followed up at 1, 3, and 6 months from initiation of the the treatment with the same assessment repeated each time.

Results

The baseline characteristics, including the symptom scores and PNIF values, were comparable between the septoplasty and the nonsurgical management groups in our study. On studying the various parameters from baseline to 6 months in the septoplasty group, there was a significant improvement in symptom scores as well as in PNIF values (p < 0.001) ([Table 1]). The improvement in symptom scores and in PNIF values was also significant in the nonsurgical management group over 6 months ([Table 2]).

Table 1 Comparison of parameters from baseline to 6 months in the septoplasty group

S. No.	Parameter	Septoplasty group				p-value[*]
		0 month	1 month	3 months	6 months
1.	VAS score Mean (SD)	6.28 (1.4)	4.42 (1.6)	3.38 (1.2)	2.9 (1)	0.001
2.	SNOT-22 Median (IQ range)	19.5 (12–24.5)	16 (10–20)	12 (10–18.7)	10 (8–16)	0.001
3.	NOSE Median (IQ range)	70 (50–80)	50 (50–60)	50 (40–58.8)	40 (30–50)	0.001
4.	PNIF R Median (IQ range) L/min	60 (40–70)	60 (50–75)	60 (52.5–80)	70 (60–80)	0.001
5.	PNIF L Median (IQ range) L/min	50 (40–70)	60 (50–70)	60 (50–80)	60 (50–80)	0.001

Abbreviations: S. No., Serial number; IQ range, Interquartile range; NOSE, nasal obstruction symptom evaluation; PNIF L, peak nasal inspiratory flow on the left side; PNIF R, peak nasal inspiratory flow on the right side; SD, Standard Deviation; SNOT-22, Sino-nasal outcome test 22; VAS, visual analogue scale.

^* Friedman test – nonparametric repeated measures.

Table 2 Comparison of parameters from baseline to 6 months in the nonsurgical management group

S. No.	Parameter	Nonsurgical management group				p-value[*]
		0 month	1 month	3 months	6 months
1.	VAS score Mean (SD)	6.0 (1.5)	4.37 (1.6)	4.33 (1.6)	5.26 (2.3)	0.001
2.	SNOT-22 Median (IQ range)	15 (10–22)	12 (10–20)	12 (10–20)	12 (8–20)	0.001
3.	NOSE Median (IQ range)	60 (50–80)	50 (40–70)	50 (25–62.5)	50 (30–70)	0.001
4.	PNIF R Median (IQ range) L/min	60 (50–80)	60 (50–80)	60 (55–85)	70 (60–90)	0.001
5.	PNIF L Median (IQ range) L/min	60 (40–72.5)	60 (50–85)	70 (50–90)	70 (50–90)	0.001

Abbreviations: S. No., Serial number; IQ range, Interquartile range; NOSE, nasal obstruction symptom evaluation; PNIF L, peak nasal inspiratory flow on the left side; PNIF R, peak nasal inspiratory flow on the right side; SD, Standard Deviation; SNOT-22, Sino-nasal outcome test 22; VAS, visual analogue scale.

^* Friedman test – nonparametric repeated measures.

On comparing the septoplasty and the nonsurgical management groups for improvement in subjective and objective measures from baseline to 1 month, there was a statistically significant difference in NOSE scores (p = 0.01) and in PNIF left side scores (p = 0.018). There was no significant difference in VAS scores (p = 0.679), SNOT-22 scores (p = 0.389), and PNIF right side values (p = 0.059) ([Table 3]). On comparing the improvement in symptom scores from baseline to 3 months in both groups, there was a significantly higher improvement in the septoplasty group when compared with the nonsurgical management group. The p-value for VAS, SNOT-22 and NOSE scores were 0.001, 0.021, and 0.035, respectively. There was also a significantly higher improvement in the septoplasty group in the objective assessment as measured by PNIF values from both the right (p = 0.003) and left side (p = 0.001) ([Table 4]). At 6 months, there was a statistically significant difference in improvement in all the symptom scores and in PNIF values between the groups ([Table 5]).

Table 3 Comparison of efficacy of treatment groups at 1 month

S.No.	Parameter	Septoplasty group		Nonsurgical management group		p-value[*]
		0 month	1 month	0 month	1 month
1.	VAS score Mean (SD)	6.28 (1.4)	4.42 (1.6)	6.0 (1.5)	4.37 (1.6)	0.679
2.	SNOT-22 Median (IQ range)	19.5 (12–24.5)	16 (10–20)	15 (10–22)	12 (10–20)	0.389
3.	NOSE Median (IQ range)	70 (50–80)	50 (50–60)	60 (50–80)	50 (40–70)	0.010
4.	PNIF R Median (IQ range)	60 (40–70)	60 (50–75)	60 (50–80)	60 (50–80)	0.059
5.	PNIF L Median (IQ range)	50 (40–70)	60 (50–70)	60 (40–72.5)	60 (50–85)	0.018

Abbreviations: S. No., Serial number; IQ range, Interquartile range; NOSE, nasal obstruction symptom evaluation; PNIF L, peak nasal inspiratory flow on the left side; PNIF R, peak nasal inspiratory flow on the right side; SD, Standard Deviation; SNOT-22, Sino-nasal outcome test 22; VAS, visual analogue scale.

^* Mann-Whitney test.

Table 4 Comparison of efficacy of treatment groups at 3 months

S.No.	Parameter	Septoplasty group		Nonsurgical management group		p-value[*]
		0 month	3 months	0 month	3 months
1.	VAS score Mean (SD)	6.28 (1.4)	3.38 (1.2)	6.0 (1.5)	4.33 (1.6)	0.001
2.	SNOT-22 Median (IQ range)	19.5 (12–24.5)	12 (10–18.7)	15 (10–22)	12 (10–20)	0.021
3.	NOSE Median (IQ range)	70 (50–80)	50 (40–58.8)	60 (50–80)	50 (25–62.5)	0.035
4.	PNIF R Median (IQ range) L/min	60 (40–70)	60 (52.5–80)	60 (50–80)	60 (55–85)	0.003
5.	PNIF L Median (IQ range) L/min	50 (40–70)	60 (50–80)	60 (40–72.5)	70 (50–90)	0.001

Abbreviations: S. No., Serial number; IQ range, Interquartile range; NOSE, nasal obstruction symptom evaluation; PNIF L, peak nasal inspiratory flow on the left side; PNIF R, peak nasal inspiratory flow on the right side; SD, Standard Deviation; SNOT-22, Sino-nasal outcome test 22; VAS, visual analogue scale.

^* Mann-Whitney test.

Table 5 Comparison of efficacy of treatment groups at 6 months

S.No.	Parameter	Septoplasty group		Nonsurgical management group		p-value[*]
		0 month	6 months	0 month	6 months
1.	VAS score Mean (SD)	6.28 (1.4)	2.9 (1)	6.0 (1.5)	5.26 (2.3)	0.001
2.	SNOT-22 Median (IQ range)	19.5 (12–24.5)	10 (8–16)	15 (10–22)	12 (8–20)	0.002
3.	NOSE Median (IQ range)	70 (50–80)	40 (30–50)	60 (50–80)	50 (30–70)	0.006
4.	PNIF R Median (IQ range) L/min	60 (40–70)	70 (60–80)	60 (50–80)	70 (60–90)	0.001
5.	PNIF L Median (IQ range) L/min	50 (40–70)	60 (50–80)	60 (40–72.5)	70 (50–90)	0.001

Abbreviations: S. No., Serial number; IQ range, Interquartile range; NOSE, nasal obstruction symptom evaluation; PNIF L, peak nasal inspiratory flow on the left side; PNIF R, peak nasal inspiratory flow on the right side; SD, Standard Deviation; SNOT-22, Sino-nasal outcome test 22; VAS, visual analogue scale.

^* Mann-Whitney test.

Discussion

A total of 140 patients were recruited in the present study. The patients were randomized into a septoplasty group (n = 70) and a nonsurgical management group (n = 70). The efficacy of each arm with respect to treatment was assessed at different timepoints, namely, baseline (0 month) and at the 1-, 3-, and 6-month post-treatment follow-up.

Out of the 140 patients with nasal obstruction due to DNS, 73 (52%) were males and 67 (48%) were females. In our study, the ratio between males and females affected by DNS was 1.1:1, which is similar to the findings seen in the study by Sriprakash.[6] In the studies by Moorthy et al. and by Sam et al., the ratio between males and females affected by DNS was 2:1.[7] [8] Sam et al. mentioned the increased occurrence of trauma among males as one of the reasons for the male preponderance in DNS with trauma being a common etiology for DNS.[8]

The ratio of DNS on the right side to DNS on the left side in our study was 1:1. In the study by Moorthy et al., DNS was more common on the left side (1.47:1).[7] A preponderance of left-sided DNS was also observed in a large Korean series by Min et al. In their study, 56% of the patients had DNS on the left side and 39% had DNS on the right. The remaining 5% had S-shaped deformity.[9]

The laterality of DNS could be affected by fetal positions in utero. A right-sided DNS occurs in the left occipitoanterior position, and vice-versa. In the study by Mogarnad et al., right-sided deviations were more common, with a right side to left side ratio of 1.3:1.[10] Serifoglu et al. also found a predominance of right-sided nasal septal deviations in their study, with 107 patients presenting with DNS to the right side and 96 patients presenting with DNS to the left.[11] This shows that there is no definite pattern in the laterality of DNS, since its cause is multifactorial.

The age range of patients with DNS in our study was between 18 and 55 years old. The average age of all the patients included in our study was 31 years old. In the study by Sam et al., the average age of the patients with DNS was 34.7 years old, and in the study by Ozkul et al., the average age was 32.31 years old, which were in line with our study.[8] [12] Possibly, the reason for this can be that patients with DNS usually present in their 3^rd decade of life with symptoms of nasal obstruction.

At the end of 6 months, 10 patients were lost to follow-up in the septoplasty group, and 13 were lost to follow-up in the nonsurgical management group. The sample size of 70 patients in each group in our study was calculated with an anticipated dropout rate of 20%. The number of patients who completed the 6 months of follow-up required for the present study was sufficient for analysis.

In the study by Stewart et al., the follow-up rate after septoplasty was of 81% after 3 months and of 65% after 6 months.[13] The follow-up rates were better in our study. Patients who underwent surgical intervention were more inclined to comply with the follow-up for the treatment than the patients in the nonsurgical management group.

The baseline characteristics such as age, gender as well as the questionnaire scores and PNIF values were comparable between the two groups in our study.

Although there was a difference in the baseline SNOT-22 scores between the septoplasty and nonsurgical management groups (19.5 versus 15), this difference was not statistically significant (p = 0.095). The mean baseline SNOT-22 score in a study by Hytönen et al. was 21.52.[14] The mean SNOT-22 score in our study on 140 patients was 18.5. The mean scores before the treatment was initiated were similar in both studies.

The normal PNIF value in healthy individuals without DNS is between 130 and 140 L/min.[12] [15] [16] In our study, the median preoperative PNIF was 60/50 L/min, and the median postoperative score at 6 months was 70/60 L/min. This could possibly be due to blocking of one nostril and measuring PNIF on the other side leading to decreased inspiratory effort.

In the septoplasty group, in the comparison of parameters from baseline to 6 months, there was a significant improvement in the VAS, SNOT-22, NOSE and PNIF scores over a period of 6 months (p = 0.001).

The nonsurgical management group also showed a significant improvement in parameters from baseline over a period of 6 months (p = 0.001).

Comparing the scores of both groups from baseline to 1 month, there was no significant difference in their efficacy (p > 0.05). This can be explained by the fact that most patients in the septoplasty group had postoperative edema and crusting in the nasal mucosa as a result of the surgical intervention.[17] This can be managed by daily regular saline nasal irrigation at home and diagnostic nasal endoscopy with suction clearance in their postoperative visit at the hospital. Nasal decongestants can be added to reduce postoperative edema. Nasal decongestants improve sinus ventilation and drainage due to their vasoconstrictor property, causing shrinkage of the turbinates and, therefore, relieving the obstruction of the osteomeatal complex.[18]

However, comparing the improvement in scores between both groups from baseline to 3 as well as 6 months, there was a significant difference in symptom scores as well as in PNIF values, with septoplasty showing better efficacy in alleviating nasal obstruction than nonsurgical management as measured by their p-value (p < 0.05).

In the study by Stewart et al., the mean NOSE scores improved from 67.5 to 26.6 from baseline to 6 months among patients who underwent surgery for DNS.[13] The median NOSE scores in the septoplasty group in our study were 70 at baseline and 40 at 6 months.

Our results are similar to those of a study by Ozkul et al., in which the mean preoperative and postoperative PNIF values were 102 L/min and 139 L/min, respectively, which showed an objective significant improvement in nasal obstruction by the septoplasty technique.[12]

A meta-analysis involving only 3 prospective controlled trials was performed by Singh et al., in which the authors demonstrated a reduction in the resistance of nasal airway following septoplasty (p = 0.018).[19]

Moore et al., in a systematic review, concluded that septoplasty improved nasal patency as reflected by objective measurements and, thus, has beneficial effects on the patients undergoing septal surgery.[20]

Hsu et al., in their retrospective cohort study, followed-up patients for 1 year before and after septoplasty with VAS, NOSE score and active anterior rhinomanometry. The patients showed a significant symptom improvement over the period of 1 year.[21]

Teixeira et al. evaluated the usefulness of PNIF in patients with nasal obstruction for objective assessment and found a positive correlation of PNIF with VAS scores.[22] Our study is the only prospective study to assess the improvement with treatment in DNS patients by all three subjective assessment scores (VAS, SNOT-22 and NOSE). An added strength to our study is the usage of an objective measurement tool in the form of PNIF values.

Our study was a well-planned prospective randomized clinical trial performed with a good sample size of 70 patients in each group. All patients in the surgical treatment group in our study underwent only septoplasty as the surgical technique. Most studies that evaluated subjective and objective parameters on DNS patients with nasal obstruction were observational or retrospective in nature or involved different types of surgical procedures and were performed with much smaller sample sizes.[23] [24] [25]

In septoplasty, DNS is straightened, causing a widening of the nasal passages. This results in improved ventilation and inspiratory effort in patients with nasal obstruction. It also improves mucociliary clearance and, therefore, improves nasal breathing.[26] [27] It also alleviates other associated symptoms of DNS such as headache, epistaxis, snoring, and sleep disturbances, therefore improving quality of life.[14] This was evident from the improvement in subjective assessment scores in our study.

Limitations of the Study

The severity of nasal obstruction based on degrees of septal deviation was not measured. The evaluation of long-term complications in both treatment groups was not studied in detail. The cost-efficacy of the treatment groups was not studied in the present study. Septoplasty surgeries were not performed by the same surgeon in our study. The types of septal deviation and their specific treatment outcomes were not studied.

Conclusion

Septoplasty is more efficacious than medical management in the long run in alleviating nasal blockade in DNS patients. Nonsurgical management is effective in a short-term basis (when used for a period of 1 month) and fails to show significant improvement thereafter. Hence, it can be considered in patients while awaiting surgery. Patients with mild to moderate DNS can be considered for a trial of nonsurgical management and, if it fails to show improvement beyond 1 month, they should be submitted to septoplasty.

Conflict of Interests

The authors have no conflict of interests to declare.

Note

The present paper was presented at the 14^th Asia Oceana ORL-HNS Congress and AOICON 2019, held at Hyderabad, India, from 9 to 13 January 2019.

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Publikationsverlauf

Eingereicht: 02. Januar 2021

Angenommen: 05. März 2021

Artikel online veröffentlicht:
23. August 2021