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Semin intervent Radiol 2021; 38(04): 419-424
DOI: 10.1055/s-0041-1735530
Review Article

Radiation Lobectomy: An Overview of Concept and Applications, Technical Considerations, Outcomes

Pouya Entezari
1   Section of Interventional Radiology, Department of Radiology, Northwestern Memorial Hospital, Chicago, Illinois
,
Ahmed Gabr
1   Section of Interventional Radiology, Department of Radiology, Northwestern Memorial Hospital, Chicago, Illinois
,
Kristie Kennedy
1   Section of Interventional Radiology, Department of Radiology, Northwestern Memorial Hospital, Chicago, Illinois
,
Riad Salem
1   Section of Interventional Radiology, Department of Radiology, Northwestern Memorial Hospital, Chicago, Illinois
2   Division of Transplantation, Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois
,
Robert J. Lewandowski
1   Section of Interventional Radiology, Department of Radiology, Northwestern Memorial Hospital, Chicago, Illinois
2   Division of Transplantation, Department of Surgery, Comprehensive Transplant Center, Northwestern University, Chicago, Illinois
› Author Affiliations Funding None declared.
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Abstract

Surgical resection has long been considered curative for patients with early-stage hepatocellular carcinoma (HCC). However, inadequate future liver remnant (FLR) renders many patients not amenable to surgery. Recently, lobar administration of yttrium-90 (Y90) radioembolization has been utilized to induce FLR hypertrophy while providing disease control, eventually facilitating resection in patients with hepatic malignancy. This has been termed “radiation lobectomy (RL).” The concept is evolving, with modified approaches combining RL and high-dose curative-intent radioembolization (radiation segmentectomy) to achieve tumor ablation. This article provides an overview of the concept and applications of RL, including technical considerations and outcomes in patients with hepatic malignancies.

Keywords

radiation lobectomy - radioembolization - future liver remnant - hepatocellular carcinoma - interventional radiology


Publication History

Article published online:
07 October 2021

© 2021. Thieme. All rights reserved.

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