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Synthesis 2022; 54(17): 3785-3792
DOI: 10.1055/s-0041-1737346
DOI: 10.1055/s-0041-1737346
special topic
Special Issue in memory of Prof. Ferenc Fülöp
Fluorinated Olefinic Lactams: The Case of Amino Acids – Preparation and Mechanistic Studies
The work was supported by the European Union through the European Social Fund under the Operational Program Knowledge Education Development (POWR.03.02.00-00-I020/17 (KSK) and POWR.03.02.00-00-I026/16 (MG)), as well as the National Science Center (UMO-2017/26/M/ST5/00437).
Abstract
Herein, we report the synthesis of analogues of amino acids with a monofluorovinyl moiety. Interestingly, we have found that cyclization of the obtained products proceeds easily in all cases. The cyclization process has not previously been observed at this reaction stage, and such fluorinated lactams derived from phenylalanine, valine, alanine have not been described before.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0041-1737346.
- Supporting Information
Publication History
Received: 01 November 2021
Accepted after revision: 11 January 2022
Article published online:
01 March 2022
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