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Am J Perinatol 2023; 40(15): 1665-1671
DOI: 10.1055/s-0041-1740178
Original Article

The Influence of Diabetes on Labor Induction with Dinoprostone Vaginal Inserts

Jennifer Y. Duffy
1   Department of Obstetrics and Gynecology, University of California, San Francisco, California
2   Department of Obstetrics and Gynecology, University of California, Irvine School of Medicine, Orange, California
,
Cindy Chau
3   Magella Medical Group, Miller Children's and Women's Hospital, Long Beach, California
,
Kyle Raymond
4   LEO Pharma A/S, Ballerup, Denmark
,
Olof Rugarn
5   Ferring Pharmaceuticals, Copenhagen, Denmark
,
Deborah A. Wing
6   Department of Academic Medicine and Health Sciences Practice, WittKieffer, Oak Brook, Illinois
7   Division of Maternal-Fetal Medicine, Department of Obstetrics-Gynecology, University of California, Orange, California
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Abstract

Objective The aim of this study was to compare duration of labor induction between diabetic and nondiabetic women receiving dinoprostone vaginal insert (10 mg).

Study Design This is a secondary analysis of two large randomized controlled trials using dinoprostone vaginal inserts for labor induction. We compare time to active labor, overall delivery, and vaginal delivery between diabetic and nondiabetic women undergoing induction of labor with a 10-mg dinoprostone vaginal insert.

Results Diabetic women receiving dinoprostone vaginal insert had a longer time to onset of active labor, overall delivery, and vaginal delivery than their nondiabetic counterparts. There was no difference in abnormal labor affecting fetal heart rate pattern in diabetic women compared with nondiabetic women. The rates of neonatal hyperbilirubinemia were higher in diabetic women.

Conclusion Diabetes may represent an independent factor associated with prolonged induction among women undergoing induction of labor with dinoprostone. Dinoprostone is well tolerated in both diabetic and nondiabetic women.

Key Points

  • Diabetic women receiving DVI have slower labor curves than nondiabetic women.

  • Nulliparous diabetic women took longer to achieve active labor, overall delivery, and vaginal delivery than nondiabetic women.

  • Parous diabetic women took longer to achieve vaginal delivery than nondiabetic women.

Key Words

dinoprostone - diabetes - induction - labor - prostaglandin


Publication History

Received: 08 September 2020

Accepted: 04 October 2021

Article published online:
02 December 2021

© 2021. Thieme. All rights reserved.

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