Video Comment on Forde et al.

Patrick F. Forde et al. Preclinical evaluation of an endoscopic electroporation system

Targeted delivery of specific chemotherapeutic drugs into tumors can be achieved by delivering electrical pulses directly to the tumor tissue. In a series of animal models, Forde et al. assessed the efficacy of electroporation delivered through a special device in combination with bleomycin. The authors found that tumor volume reduced significantly, with cell death being induced rapidly, mainly via an apoptotic-type mechanism. This novel therapy may become an addition to the endoscopist’s armamentarium for the treatment of gastrointestinal cancer.