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Planta Med 2017; 83(01/02): 111-116
DOI: 10.1055/s-0042-107252
DOI: 10.1055/s-0042-107252
Natural Product Chemistry and Analytical Studies
Original Papers
Diterpenoid Alkaloids from Delphinium ajacis and Their Anti-RSV Activities
Further Information
Publication History
received 30 November 2015
revised 06 April 2016
accepted 15 April 2016
Publication Date:
12 July 2016 (online)
Abstract
Five new diterpenoid alkaloids, ajacisines A–E (1–5), were isolated from Delphinium ajacis, along with seven known alkaloids (6–12). On the basis of their spectral data (IR, UV, HR-ESI-MS, 1D and 2D NMR) and chemical properties, the structures of compounds 1–12 were identified. All isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus, and compounds 3–5 and 8 exhibited moderate to weak effects with IC50 values of 75.2 ± 1.1, 35.1 ± 0.6, 10.1 ± 0.3, and 50.2 ± 0.5 µM, respectively.
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