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Dtsch Med Wochenschr 2017; 142(08): 586-594
DOI: 10.1055/s-0042-109889
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© Georg Thieme Verlag KG Stuttgart · New York

Parachute-Implantation bei schwerer ischämischer Herzinsuffizienz

Parachute Implantation in Severe Ischemic Cardiomyopathy
Sebastian Reith
,
Wiebke Kaestner
,
Nikolaus Marx
,
Mathias Burgmaier
Further Information

Publication History

Publication Date:
21 April 2017 (online)

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Abstract

Congestive heart failure related to myocardial infarction is characterized by left-ventricular remodeling and moreover it is associated with significant morbidity and mortality with currently limited therapeutic options. The catheter-based left ventricular partitioning device (ParachuteTM, CardioKinetix, Inc., Menlo Park, CA) is a novel therapeutic option available for patients with severe systolic dysfunction following antero-apical myocardial infarction with regional wall motion abnormalities. Preliminary clinical data indicate in addition to the safety the improvement in left ventricular hemodynamics, functional capacity and quality of life.

Die Herzinsuffizienz als Folge eines Myokardinfarktes geht mit einer hohen Morbidität und Mortalität einher; die Therapieoptionen sind begrenzt. Vielversprechend ist hier das ventrikuläre Partitionierungsverfahren, bei dem die Implantation des „Parachute-Device“ die Kontraktilität des linken Ventrikels erhöht. Dadurch verbessern sich Hämodynamik und funktionelle Kapazität – und nicht zuletzt auch die Lebensqualität der Patienten.

Schlüsselwörter

parachute device - perkutane ventrikuläre Restauration - ischämische Kardiomyopathie - linksventrikuläres Remodeling - Herzinsuffizienz

Key words

parachute device - percutaneous ventricular restoration - ischemic cardiomyopathy - left ventricular remodeling - heart failure
 

  • Literatur

  • 1 Costa MA. Pencina M. Nikolic S. et al. The PARACHUTE IV trial design and rationale: percutaneous ventricular restoration using the parachute device in patients with ischemic heart failure and dilated left ventricles. Am Heart J 2013; 165: 531-536
    CrossrefPubMedSearch in Google Scholar
  • 2 Stone PH. Raabe DS. Jaffe AS. et al. Prognostic significance of location and type of myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll Cardiol 1988; 11: 453-463
    CrossrefPubMedSearch in Google Scholar
  • 3 Ambrosy AP. Foranow GC. Butler J. et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014; 63: 1123-1133
    CrossrefPubMedSearch in Google Scholar
  • 4 Jhund PS. McMurray JJ. Heart failure after acute myocardial infarction: a lost battle in the war on heart failure?. Circulation 2008; 118: 2019-2021
    CrossrefPubMedSearch in Google Scholar
  • 5 Fang F. Liu W. Zhao YX. et al. The patient's selection of PARACHUTE® endoventricular partitioning device: The important role of detailed echocardiography. Int J Cardiol 2015; 195: 176-179
    CrossrefPubMedSearch in Google Scholar
  • 6 Cilingiroglu M. Rollefson WA. Mego D. Percutaneous implantation of a parachute device for treatment of ischemic heart failure. Cardiovasc Revasc Med 2013; 14: 236-240
    CrossrefPubMedSearch in Google Scholar
  • 7 Schmidt T. Frerker C. Thielsen T. et al. New evidence for favourable effects on haemodynamics and ventricular performance after Parachute(®) implantation in humans. Eur J Heart Fail 2014; 16: 1112-1119
    PubMedSearch in Google Scholar
  • 8 Stone PH. Raabe DS. Jaffe AS. et al. Prognostic significance of location and type of myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll Cardiol 1988; 11: 453-463
    CrossrefPubMedSearch in Google Scholar
  • 9 Pfeffer MA. Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81: 1161-1172
    CrossrefPubMedSearch in Google Scholar
  • 10 Sutton MGSJ. Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 2000; 101: 2981-2988
    CrossrefPubMedSearch in Google Scholar
  • 11 Thomas M. Nienaber CA. Ince H. et al. Percutaneous ventricular restoration (PVR) therapy using the Parachute device in 100 subjects with ischaemic dilated heart failure: one-year primary endpoint results of PARACHUTE III, a European trial. EuroIntervention 2015; 11: 710-717
    CrossrefPubMedSearch in Google Scholar
  • 12 Gaudron P. Eilles C. Kugler I. et al. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation 1993; 87: 755-763
    CrossrefPubMedSearch in Google Scholar
  • 13 Pfeffer MA. Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990; 81: 1161-1167
    CrossrefPubMedSearch in Google Scholar
  • 14 Chen J. Normad SL. Wang Y. et al. National and regional trends in heart failure hospitalization and mortality rates for Medicare benificiaries, 1998–2008. JAMA 2011; 306: 1669-1678
    CrossrefPubMedSearch in Google Scholar
  • 15 Udelson JE. Feldman AM. Greenberg B. Randomized double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-moderate heart failure and left ventricular dysfunction. Circ Heart Fail 2010; 3: 347-353
    CrossrefPubMedSearch in Google Scholar
  • 16 Colucci WS. Kolias TJ. Adams KF. et al. Metoprolol reverses left ventricular remodeling in patients with asymptomatic systolic dysfunction: the REversal of VEntricular Remodeling with Toprol-XL (REVERT) trial. Circulation 2007; 116: 49-56
    CrossrefPubMedSearch in Google Scholar
  • 17 Kelesidis I. Varughese CJ. Hourani P. et al. Effects of β-adrenergic blockade on left ventricular remodeling among Hispanics and African Americans with chronic heart failure. Clin Cardiol 2013; 36: 595-602
    PubMedSearch in Google Scholar
  • 18 Athanasuleas CL. Buckberg GD. Stanley AW. et al. Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation. J Am Coll Cardiol 2004; 44: 1439-1445
    CrossrefPubMedSearch in Google Scholar
  • 19 Buckberg GD. Athanasuleas CL. Wechsler AS. et al. The STICH trial unravelled. Eur J Heart Fail 2010; 12: 1024-1027
    CrossrefPubMedSearch in Google Scholar
  • 20 Jones RH. Velazquez EJ. Michler RE. et al. Coronary bypass surgery with or without surgical ventricular reconstruction. N Engl J Med 2009; 360: 1705-1717
    CrossrefPubMedSearch in Google Scholar
  • 21 Oh JK. Pellikka PA. Panza JA. et al. Core lab analysis of baseline echocardiographic studies in the STICH trial and recommendation for use of echocardiography in future clinical trials. J Am Soc Echocardiogr 2012; 25: 317-324
    PubMedSearch in Google Scholar
  • 22 Burton NA. Stinson EB. Oyer PE. et al. Left ventricular aneurysm. Preoperative risk factors and long-term postoperative results. J Thorac Cardiovasc Surg 1979; 77: 65-75
    PubMedSearch in Google Scholar
  • 23 Olearchyk AS. Lemole GM. Spagna PM. Left ventricular aneurysm. Ten years' experience in surgical treatment of 244 cases. Improved clinical status, hemodynamics, and long-term longevity. J Thorac Cardiovasc Surg 1984; 88: 544-553
    PubMedSearch in Google Scholar
  • 24 Shroyer AL. Collins JF. Grover FL. et al. Evaluating clinical applicability: the STICH trial`s findings. J Am Coll Cardiol 2010; 56: 508-509
    CrossrefPubMedSearch in Google Scholar
  • 25 Ige M. Al-Kindi SG. Attizzani G. et al. Percutaneous left ventricular restoration. Heart Failure Clin 2015; 11: 261-273
    CrossrefPubMedSearch in Google Scholar
  • 26 Schäfer U. Left ventricular partitioning in systolic heart failure subjects: addressing a mechanistic void with current therapies. EuroIntervention 2016; 12: 93-96
    PubMedSearch in Google Scholar
  • 27 Menon PG. Ludwig D. Lacomis J. et al. Computed tomographic analysis of left ventricular volumes and function after implantation of the Parachute® endoventricular partitioning device. J Interv Cardiol 2014; 27: 604-609
    CrossrefPubMedSearch in Google Scholar
  • 28 Otasevic P. Sagic M. Antonic Z. et al. First-in-man implantation of left ventricular partitioning device in a patient with chronic heart failure: twelve month follow-up. Journal of cardiac failure 2007; 13: 517-520
    CrossrefPubMedSearch in Google Scholar
  • 29 Mazzaferri Jr EL. Gradinac S. Sagic D. et al. Percutaneous left ventricular partitioning in patients with chronic heart failure and a prior anterior myocardial infarction: Results of the PercutAneous Ventricular RestorAtion in Chronic Heart failUre PaTiEnts Trial. Am Heart J 2012; 163: 812-820.e1
    CrossrefPubMedSearch in Google Scholar
  • 30 Konstam MA. Kramer DG. Patel AR. et al. Left ventricular remodeling in heart failure: current concepts in clinical significance and assessment. JACC Cardiovasc Imaging 2011; 4: 98-108
    CrossrefPubMedSearch in Google Scholar
  • 31 White HD. Norris RM. Brown MA. et al. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 1987; 76: 44-51
    CrossrefPubMedSearch in Google Scholar
  • 32 Kramer DG. Trikalinos TA. Kent DM. et al. Quantitative evaluation of drug and device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach. J Am Coll Cardiol 2010; 56: 392-406
    CrossrefPubMedSearch in Google Scholar
  • 33 Kjekshus J. Apetrei E. Barrios V. CORONA Group. et al. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007; 357: 2248-2261
    CrossrefPubMedSearch in Google Scholar
  • 34 Bilchick KC. Kamath S. DiMarco JP. et al. Bundle-branch block morphology and other predictors of outcome after cardiac resynchronization therapy in Medicare patients. Circulation 2010; 122: 2022-2030
    CrossrefPubMedSearch in Google Scholar
  • 35 Yang Yang YJ. Huo Y. Xu YW. et al. Percutaneous Ventricular Restoration Therapy Using the Parachute Device in Chinese Patients with Ischemic Heart Failure: Three-Month Primary End-point Results of PARACHUTE China Study. Chin Med J (Engl) 2016; 129: 2058-2062
    PubMedSearch in Google Scholar