Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity

Orsolya Roza; Ana Martins; Judit Hohmann; Wan-Chun Lai; Jacobus Eloff; Fang-Rong Chang; Dezső Csupor

doi:10.1055/s-0042-110656

Planta Medica, Inhaltsverzeichnis

Planta Med 2016; 82(14): 1274-1278
DOI: 10.1055/s-0042-110656

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Flavonoids from Cyclopia genistoides and Their Xanthine Oxidase Inhibitory Activity

Orsolya Roza

¹Department of Pharmacognosy, University of Szeged, Szeged, Hungary

,

Ana Martins

¹Department of Pharmacognosy, University of Szeged, Szeged, Hungary

,

Judit Hohmann

¹Department of Pharmacognosy, University of Szeged, Szeged, Hungary

²Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary

,

Wan-Chun Lai

³Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

,

Jacobus Eloff

⁴Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Pretoria, South Africa

,

Fang-Rong Chang

³Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

,

Dezső Csupor

¹Department of Pharmacognosy, University of Szeged, Szeged, Hungary

²Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary

› Institutsangaben

Abstract

The present paper reports the chemical analysis of the methanolic extracts of fermented and non-fermented Cyclopia genistoides herbs and an investigation of the xanthine oxidase inhibitory activity of the isolated constituents. Chemical analysis of the leaves and stems of C. genistoides yielded the isolation and identification of two benzophenone glucosides, iriflophenone 2-O-β-glucopyranoside (1) and iriflophenone 3-C-β-glucopyranoside (2), two pterocarpans, (6aR,11aR)-(−)-2-methoxymaackiain (5) and (6aR,11aR)-(−)-maackiain (6), along with the flavanones liquiritigenin (9) and hesperetin (10), the flavone diosmetin (11), the isoflavones afrormosin (7) and formononetin (8), piceol (3), and 4-hydroxybenzaldehid (4). Among the eleven compounds, nine are reported for the first time from this species, and six from the genus Cyclopia. These compounds, together with previously isolated secondary metabolites of this species, were tested for xanthine oxidase inhibitory activity. The 5,7-dihydroxyflavones luteolin and diosmetin significantly inhibited the enzyme in vitro, while hesperetin (10) and 5,7,3′,5′-tetrahydroxyflavone exerted weak activity.

Key words

xanthine oxidase - Cyclopia genistoides - gout - flavonoid - benzophenone - honeybush - Fabaceae

Volltext

Referenzen

References
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