A 35-year-old patient presented with a 1-month history of fever, fatigue, and loss
of weight and appetite. Clinical examination was unremarkable except for hypotension
(90/60 mmHg). The cause of fever could not be ascertained from routine investigations.
Biochemistry results were: serum albumin 2.8 gm/dL, international normalized ratio
1.4, serum cortisol 4 µg/dL, serum sodium 122 mEq/L, and serum potassium 5.8 mEq/L.
A contrast-enhanced abdominal computed tomography (CT) scan showed bilateral adrenal
enlargement. Positron emission tomography (PET)-CT showed uptake only in the adrenal
glands on both sides ([Fig. 1]). Endoscopic ultrasound (EUS) showed a 5 × 4 cm well-defined, hypoechoic, left adrenal
mass, with a definite outline ([Fig. 2 a]). The right adrenal gland showed a 4 × 3 cm mass ([Fig. 2 b]). EUS-guided fine-needle aspiration (FNA) was performed on the left adrenal gland
([Video 1]).
Fig. 1 Positron emission tomography – computed tomography scan showing the uptake in both
adrenal glands (arrows).
Fig. 2 Endoscopic ultrasound images. a Left adrenal mass. b Right adrenal mass.
Endoscopic ultrasound-guided fine-needle aspiration of the left adrenal gland.
Cytology revealed numerous acid-fast bacilli against a necrotic background ([Fig. 3]). A diagnosis of adrenal insufficiency secondary to tuberculosis was made, and treatment
with corticosteroids for adrenal insufficiency and antitubercular therapy was started.
Patient symptoms showed improvement within 2 weeks.
Fig. 3 Acid-fast bacilli against a background of necrotic cells.
Differential diagnosis of bilateral enlarged adrenal glands includes infections such
as tuberculosis, histoplasmosis, neoplastic masses (malignant metastases, adrenal
carcinoma, pheochromocytoma, lymphoma), and autoimmune disease (Addison’s disease)
[1]
[2]. Tissue diagnosis can be undertaken by ultrasound, CT or EUS-guided FNA of adrenal
glands. Various approaches have been used for ultrasound and CT-guided adrenal sampling.
Complications occur in 2.8 % – 8.4 % of cases and include adrenal hematoma, pneumothorax,
perinephric hemorrhage, pain, needle-tract metastasis, and pancreatitis [3]. EUS-guided adrenal FNA has emerged as a safe alternative to ultrasound and CT-guided
adrenal FNA [4]. Advantages of the EUS-guided approach include proximity to the left adrenal gland
thus avoiding passage through other organs, real-time monitoring of needle passage,
and high accuracy for adrenal identification. The accuracy of transabdominal ultrasound
for adrenal identification is 70 % for the left adrenal gland and 90 % for the right
gland [5]. Hence, complication rates are lower with EUS-guided FNA than with percutaneous
approaches [5].
Endoscopy_UCTN_Code_CCL_1AF_2AZ
