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Horm Metab Res 2016; 48(09): 565-570
DOI: 10.1055/s-0042-112127
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

Thyroid Function and its Implications in Oxidative Stress Influencing the Pathogenesis of Osteoporosis in Adults with Down Syndrome: A Cohort Study

E. R. Villani
1   Department of Geriatrics “Centro Medicina dell’Invecchiamento”, Catholic University of the Sacred Heart, Rome, Italy
,
G. Onder
1   Department of Geriatrics “Centro Medicina dell’Invecchiamento”, Catholic University of the Sacred Heart, Rome, Italy
,
A. Carfì
1   Department of Geriatrics “Centro Medicina dell’Invecchiamento”, Catholic University of the Sacred Heart, Rome, Italy
,
C. Di Segni
2   Division of Endocrinology, Department of Medical Sciences, Catholic University of the Sacred Heart, Rome, Italy
,
S. Raimondo
2   Division of Endocrinology, Department of Medical Sciences, Catholic University of the Sacred Heart, Rome, Italy
,
A. Silvestrini
3   Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy
,
E. Meucci
3   Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy
,
A. Mancini
2   Division of Endocrinology, Department of Medical Sciences, Catholic University of the Sacred Heart, Rome, Italy
› Author Affiliations
Further Information

Publication History

received 12 March 2016

accepted 07 July 2016

Publication Date:
24 August 2016 (online)

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Abstract

People with Down syndrome (DS) show lower bone mass density (BMD) and a higher prevalence of hypothyroidism compared to general population. Furthermore, DS is a well-known high oxidative stress (OS) condition because genes involved in OS map on chromosome 21. Thyroid function too is involved in OS. Since both thyroid function and OS lead to lower BMD and osteoporotic fractures, we have explored correlations among BMD, thyroid hormones, and parameters of OS in DS adults. A total of 105 DS patients (48 males; 21–71 years; mean BMI 28.88±7.12 kg/m2) were enrolled in a cohort study, 48 of them undergoing thyroid replacement therapy. We evaluated thyroid function, BMD, and total antioxidant capacity (TAC) in blood plasma. TAC was assayed by H2O2-metmyoglobin system, as source of radicals, and by the chromogenous ABTS, with a latency time (LAG) in the appearance of its cation ABTS+proportional to antioxidant concentration. BMD was evaluated with DEXA, using WHO criteria to classify osteoporosis. Low BMD was found in 83.78% of patients. TSH and LAG did not correlate with BMD. Nevertheless, LAG significantly correlates to Z-scores estimated at the lumbar spine (r2=0.558; p=0.03) in hypothyroid patients. Our data show that low TAC could be more associated with reduced BMD rather than TSH itself in DS patients and that the OS could have a role in the pathogenesis of osteoporosis regarding the hypothyroid subgroup.

Key words

bone mineral density - down syndrome - oxidative stress - thyroid function - total antioxidant capacity
 

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