Innovationen in der Onkologie

Zusammenfassung

Analysiert man die aktuellen Arzneimittelentwicklungen in der klinischen Onkologie, so fällt auf, dass nur noch wenige neue Zytostatika vorgestellt werden, während es neben den zielgerichtet wirksamen Tumortherapeutika vor allem die Checkpoint-Inhibitoren sind, bei denen in kurzer Zeit nicht nur relativ viele neue Wirkstoffe, son­dern auch weitergehende Anwendungsgebiete vorgestellt werden. Auch mit onkolytischen Viren wird die Reaktivierung spezifischer T-Lymphozyten verfolgt, sodass zum gegenwärtigen Zeitpunkt die Strategie der spezifisch wirksamen Immunmodulation die Diskussion zu innovativen Therapiestrategien beherrscht.

Summary

Current drug development in clinical oncology is primarily focused on targeted thera­peutic agents as well as checkpoint inhibitors whereas novel cytotoxic drugs appear to be of minor quantitative importance. Particularly, the strategies based on reactiva­tion of the specifically acting immune system including oncolytic viruses, dominate the ongoing discussion regarding innovative therapeutics.

Schlüsselwörter

Arzneimittelentwicklungen - Zytostatika - zielgerichtete Therapien - Checkpoint-Inhibitoren - spezifische Immunmodulation

Keywords

Drug developments - cytotoxic drugs - targeted therapeutics - checkpoint- inhibitors - specific immunomodulation

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