Neues zur Therapie der chronisch-entzündlichen Darmerkrankungen

Zusammenfassung

Durch ein verbessertes Verständnis der multifaktoriellen Immunpathogenese der CED konnten in den letzten Jahren zahlreiche neue Substanzen entwickelt oder bereits zur Therapie von Morbus Crohn oder Colitis ulcerosa zugelassen werden. Diese umfassen z. B. Antikörper gegen IL-12 / 23, anti-Adhäsionsmolekül-Antikörper und Antisense-Oligonukleotide. Die Vielzahl der zukünftig verfügbaren Therapien wird zu einer Veränderung der aktuell angewandten Therapiealgorithmen führen. Marker für eine verbesserte individualisierte Therapieentscheidung werden für eine effektivere Behandlung von CED-Patienten dringend benötigt.

Abstract

Increasing knowledge regarding the immunopathogenesis of IBD has led to the development or approval of novel therapeutic agents for the treatment of Crohn’s disease or ulcerative colitis. The new substances for example include antibodies against IL-12 / 23, anti-adhesion molecules and antisense oligonucleotides. The increase of therapeutic options will lead to a change of currently used therapeutic algorithms. Biomarkers to ensure a more individualized therapeutic approach are urgently needed to improve an efficient therapy of IBD patients.

Schlüsselwörter

Morbus Crohn - Colitis ulcerosa - Biologika - Oligonukleotide

Keywords

Crohn’s disease - ulcerative colitis - biologicals - oligonucleotides

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