Dtsch Med Wochenschr 2017; 142(03): 217-224
DOI: 10.1055/s-0042-120574
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Prävention von Infekten der oberen Atemwege

Prevention of Infections of the Upper Respiratory Tract
Sebastian Voß
,
Rieke Schnakenberg
,
Klaus Weckbecker
,
Markus Bleckwenn
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
10. Februar 2017 (online)

Abstract

Because of its high prevalence acute respiratory diseases have a significant impact on the population. The focus of this review was the current state of knowledge for the prophylactic efficacy of: zinc, vitamin C, Echinacea preparations, garlic and carrying out physical measures. Furthermore, the benefits of pneumococcal and influenza vaccine were elicited. In the synopsis, the physical measures proved to be the most effective, cost-effective method to prevent infections. The intake of zinc, Echinacea preparations (for example: E. purpurea), vitamin C and garlic showed moderate success in the prevention of infection and must be elicited individually. Pneumococcal and annual influenza vaccines in family practice should be given furthermore accordingly topical STIKO-recommendation. Nevertheless, the prophylactic effect from influenza vaccines on usual cold illnesses is unsettled.

Akute respiratorische Erkrankungen (ARE) gehören zu den häufigsten Erkrankungen in den industrialisierten Staaten. Symptome divergieren in Dauer und Intensität. Sie schränken den Patienten in seinem Allgemeinbefinden oft derart ein, dass eine Arbeitsunfähigkeit resultiert. Um für die Patientenberatung eine aktuelle Übersicht zu haben, wurde eine Literaturrecherche zum Thema „Infektprophylaxe“ durchgeführt.

 
  • Literatur

  • 1 Heikkinen T. Järvinen A. The common cold. Lancet 2003; 361: 51-59
  • 2 Schnabel E. Sausenthaler S. Brockow I. et al. Burden of otitis media and pneumonia in children up to 6 years of age: results of the LISA birth cohort. Eur J Pediatr 2009; 168: 1251-1257
  • 3 Robert- Koch- Institut. Wochenberichte GrippeWeb 28/2016 (18.07.2016). Im Internet: https://grippeweb.rki.de/Results.aspx Stand: 27.07.2016
  • 4 Robert-Koch-Institut. Bevölkerungsbasierte Erhebung der Häufigkeit von akuten Atemwegserkrankungen. Epidemiol Bull 2011; 37: 343-350
  • 5 Marrie TJ. Lau CJ. Wheeler SL. et al. A controlled trial of a critical pathway for treatment of community-acquired pneumonia. CAPITAL Study Investigators. Community-Acquired Pneumonia Intervention Trial Assessing Levofloxacin. JAMA 2000; 283: 749-755
  • 6 Welte T. Köhnlein T. Global and local epidemiology of community-acquired pneumonia: the experience of the CAPNETZ Network. Semin Respir Crit Care Med 2009; 30: 127-135
  • 7 Johnson C. Eccles R. Acute cooling of the feet and the onset of common cold symptoms. Fam Pract 2005; 22: 608-613
  • 8 Foxman EF. Storer JA. Fitzgerald ME. et al. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proc Natl Acad Sci USA 2015; 112: 827-832
  • 9 Cohen S. Tyrrell DA. Smith AP. Psychological stress and susceptibility to the common cold. N Engl J Med 1991; 325: 606-612
  • 10 Prasad AS. Beck FW. Bao B. et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr 2007; 85: 837-844
  • 11 Singh M. Das RR. Zinc for the common cold. Cochrane Database Syst Rev 2011; 2 DOI: 10.1002/14651858.CD001364.pub3.
  • 12 Singh M. Das RR. Zinc for the common cold. Cochrane Database Syst Rev 2013; 6 DOI: 10.1002/14651858.CD001364.pub4.
  • 13 Kurugöl Z. Akilli M. Bayram N. et al. The prophylactic and therapeutic effectiveness of zinc sulphate on common cold in children. Acta Pæd 2006; 95: 1175-1181
  • 14 Vakili R. Vahedian M. Khodaei GH. et al. Effects of zinc supplementation in occurrence and duration of common cold in school aged children during cold season: a double-blind placebo-controlled trial. Iran J Pediatr 2009; 19: 376-380
  • 15 Kartasurya MI. Ahmed F. Subagio HW. et al. Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia. Br J Nutr 2012; 108: 2251-2260
  • 16 Rerksuppaphol S. Rerksuppaphol L. A randomized controlled trial of chelated zinc for prevention of the common cold in Thai school children. Paediatr Int Child Health 2013; 33: 145-150
  • 17 Singh M. Das RR. WITHDRAWN: Zinc for the common cold. Cochrane Database Syst Rev 2015; DOI: 10.1002/14651858.CD001364.pub5.
  • 18 Chalmers TC. Effects of ascorbic acid on the common cold. Am J Med 1975; 58: 532-536
  • 19 Hemilä H. Herman ZS. Vitamin C and the common cold: a retrospective analysis of Chalmers’ review. J Am Coll Nutr 1995; 14: 116-123
  • 20 Hemilä H. Chalker E. Preventing the common cold. Cochrane Database Syst Rev 2013; DOI: 10.1002/14651858.CD000980.pub4.
  • 21 Hemilä H. Thomas Chalmers, vitamin C and the common cold. J R Soc Med 2016; 109: 46-46
  • 22 Hunt C. Chakravorty N. Annan G. et al. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam Nutr Res 1994; 3: 212-219
  • 23 Cathcart RF. Vitamin C, titrating to bowel tolerance, anascorbemia, and acute induced scurvy. Med Hypotheses 1981; 7: 1359-1376
  • 24 Barrett B. Medicinal properties of Echinacea: A critical review. Phytomedicine 2003; 10: 66-86
  • 25 Shah SA. Sander S. White CM. et al. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis 2007; 7: 473-480
  • 26 Linde K. Barrett B. Wölkart K. et al. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2006; DOI: 10.1002/14651858.CD000530.pub2.
  • 27 Karsch-Völk M. Berraett B. Kiefer D. et al. Echinacea für preventing and treating the common cold. Cochrane Database Syst Rev 2014; DOI: 10.1002/14651858.CD000530.pub3.
  • 28 Jawad M. Schoop R. Suter A. et al. Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial. Evid Based Complement Altern Med 2012; 841315
  • 29 Ross SM. Echinacea purpurea: A Proprietary Extract of Echinacea purpurea Is Shown to be Safe and Effective in the Prevention of the Common Cold. Holist Nurs Pract 2016; 30: 54-57
  • 30 Allan GM. Arroll B. Prevention and treatment of the common cold: making sense of the evidence. Can Med Assoc J 2014; 186: 190-199
  • 31 Ankri S. Mirelmann D. Antimicrobial properties of allicin from garlic. Microbes Infect 1999; 1 (02) 125-129
  • 32 Lissiman E. Bhasale AL. Cohen M. Garlic for the common cold. Cochrane Database Syst Rev 2012; DOI: 10.1002/14651858.CD006206.pub3.
  • 33 Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther 2001; 18: 189-193
  • 34 Lissiman E. Bhasale AL. Cohen M. Garlic for the common cold. Cochrane Database Syst Rev 2014; DOI: 10.1002/14651858.CD006206.pub4.
  • 35 Percival SS. Aged Garlic Extract Modifies Human Immunity. J Nutr 2016; 146: 433-436
  • 36 Jefferson T. Del Mar CB. Dooley L. et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev 2011; DOI: 10.1002/14651858.CD006207.pub4.
  • 37 Lee KM. Shukla VK. Clark M. et al. Physical Interventions to Interrupt or Reduce the Spread of Respiratory Viruses — Resource Use Implications: A Systematic Review. Canadian Agency for Drugs and Technologies in Health. (22.08.2012). Im Internet: Im Internet: https://www.cadth.ca/physical-interventions-to-interrupt-or-reduce-spread-respiratory-viruses-resource-use-implications Stand: 22.02.2016
  • 38 Little P. Stuart B. Hobbs FD. et al. An internet-delivered handwashing intervention to modify influenza-like illness and respiratory infection transmission (PRIMIT): a primary care randomised trial. Lancet 2015; 386: 1631-1639
  • 39 Lee KM. Shukla VK. Clark M. et al. Physical Interventions to Interrupt or Reduce the Spread of Respiratory Viruses — Resource Use Implications: A Systematic Review. Canadian Agency for Drugs and Technologies in Health. (22.08.2012). Im Internet: https://www.cadth.ca/physical-interventions-to-interrupt-or-reduce-spread-respiratory-viruses-resource-use-implications Stand: 20.7.2016
  • 40 Lode HM. Stahlmann R. Impfungen in der Pneumologie. HNO 2015; 63: 649-660
  • 41 Ewald H. Briel M. Vuichard D. et al. The Clinical Effectiveness of Pneumococcal Conjugate Vaccines: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Dtsch Ärztebl Int 2016; 113: 139-146
  • 42 Buda S. Köpke K. Prahm K. Bericht zur Epidemiologie der Influenza in Deutschland Saison 2012/13. 2013 Im Internet: http://influenza.rki.de/Saisonbericht.aspx Stand: 24.07.2016
  • 43 Influenza zugeschriebene Mortalität – aktuelle Zahlen bis Saison 2012/2013. Epidemiol Bull RKI; 2015
  • 44 Forcades i Vila T. Flu Vaccination: The Gap Between Evidence and Public Policy. Int J Health Serv Plan Adm Eval 2015; 45: 453-470
  • 45 Jefferson T. Influenza vaccination: policy versus evidence. BMJ 2006; 333: 912-915
  • 46 Jackson M. Nelson J. Weiss N. et al. Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study. Lancet 2008; 372: 398-405
  • 47 Rizzo C. Viboud C. Montomoli E. et al. Influenza-related mortality in the Italian elderly: no decline associated with increasing vaccination coverage. Vaccine 2006; 24: 6468-6475
  • 48 Jefferson T. Di Pietrantonj C. Rivetti A. et al. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev 2014; DOI: 10.1002/14651858.CD001269.pub5.
  • 49 Thomas RE. Jefferson T. Lasserson TJ. Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions. Cochrane Database Syst Rev 2016; DOI: 10.1002/14651858.CD005187.pub5.
  • 50 Emborg HD. Krause TG. Nielsen L. et al. Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 – a rapid epidemiological and virological assessment. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull 2016; DOI: 10.2807/1560-7917.ES.2016.21.14.30189.
  • 51 Eurich DT. Marrie TJ. Johnstone J. et al. Mortality reduction with influenza vaccine in patients with pneumonia outside ‘flu’ season: pleiotropic benefits or residual confounding?. Am J Respir Crit Care Med 2008; 178: 527-533
  • 52 Manzoli L. Ioannidis JP. Flacco ME. et al. Effectiveness and harms of seasonal and pandemic influenza vaccines in children, adults and elderly: a critical review and re-analysis of 15 meta- analyses. Hum Vaccin Immunother 2012; 8: 851-862
  • 53 Talbot HK. Libster R. Edwards KM. Influenza vaccination for older adults. Hum Vaccin Immunother 2012; 8: 96-101
  • 54 Soriano A. Varrecchia E. Marinaro A. et al. Giant cell arteritis and polymyalgia rheumatica after influenza vaccination: report of 10 cases and review of the literature. Lupus 2012; 21: 153-157
  • 55 Fu MH. Tsai WC. Lan J. et al. Churg-Strauss Syndrome Following Vaccination Against 2010 Influenza A (H1N1): A Case Report. Acta Neurol Taiwan 2014; 23: 95-101
  • 56 Papke D. Mc Nussen PJ. Rasheed M. et al. A Case of Unilateral Optic Neuropathy Following Influenza Vaccination. Semin Ophthalmol 2016; DOI: 10.3109/08820538.2015.1120758.