Role of the Mesentery in Crohn's Terminal Ileitis

Marte A.J. Becker; Eline M.L. van der Does de Willebois; Willem A. Bemelman; Manon E. Wildenberg; Christianne J. Buskens

doi:10.1055/s-0042-1743589

Clinics in Colon and Rectal Surgery, Inhaltsverzeichnis

Clin Colon Rectal Surg 2022; 35(04): 316-320
DOI: 10.1055/s-0042-1743589

Review Article

Role of the Mesentery in Crohn's Terminal Ileitis

Marte A.J. Becker

¹Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology & Metabolism, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

,

Eline M.L. van der Does de Willebois

²Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands

,

Willem A. Bemelman

²Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands

,

Manon E. Wildenberg

¹Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology & Metabolism, Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

,

Christianne J. Buskens

²Department of Surgery, Amsterdam UMC, location AMC, Amsterdam, The Netherlands

› Institutsangaben

Abstract

Despite the longstanding awareness of the presence of mesenteric alterations in Crohn's disease, the functional and clinical consequences of these alterations remain a topic of debate. Guidelines advise a limited resection without resection of the adjacent mesentery to prevent short bowel syndrome and postoperative complications. However, recently mesenteric resection has been proposed as an alternative to reduce recurrence rates in Crohn's disease patients. Here, we evaluate the data available on this topic in terminal ileitis, both from a fundamental research point of view and clinical perspective.

Keywords

Crohn's disease - mesentery - macrophages - ileocecal resection

Volltext

Referenzen

References
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