Introduction
“Multimorbidity”, defined as the co-existence of two or more chronic conditions in
an individual,[1] significantly affects the elderly and incurs a heavy burden on health care.[2] According to the WHO's Study on Global Aging and Adult Health (SAGE) in India, 60.7%
of those aged 70 and more, and 12.3% of those aged 18 to 49, reported having multiple
chronic conditions.[3] The rapid growth in non-communicable diseases and the persistence of infectious
diseases are combining to make multimorbidity a major public health challenge in the
BRICS nations.[4] The gravity of this public health issue can be weighed through its effects on the
ability to work and on employability, disability and mortality within the population.[5] Furthermore, because clinical treatments frequently focus on one disease at a time,
people with multimorbidity have difficulty adhering to therapy and have lower quality
of life.[5]
In such a situation, a therapy that is both cost-effective and comprehensive would
be highly desirable. Based on a holistic therapeutic strategy and patient-centered
care, the homeopathic system of medicine can deliver both cost-effective and complete
medical care.[6] Randomized controlled trials (RCTs),[7]
[8] observational studies[9]
[10]
[11] and case reports[12]
[13] on the management of the different clinical conditions manifested in the case under
study have shown varying success.
There have also been case reports on the benefits of homeopathy in multimorbidity.[14]
[15]
[16] In support of a positive role of homeopathy, there is a published case report of
the homeopathic management of multimorbidity (severe climacteric syndrome, pelvic
inflammatory disease, dyslipidemia, obesity, hepatic steatosis, pancreatic lipomatosis,
gall bladder disease, and mild subclinical hypothyroidism) after surgical menopause.[14] In another study, two siblings with multimorbidity – i.e., dyslexia, dyspraxia,
asthma, eczema, hypertonia, recurrent urinary tract infections, allergies – were treated
by a homeopath employing a variety of homeopathic methods and medicines over a period
of 1 year. This resulted in improvements in ADHD status, patient-generated outcomes
and parent-reported pathology, and a reduction in conventional medication.[15]
In the present case study, homeopathic management of multimorbidity comprising five
clinical conditions – namely fibroid uterus, fibroadenosis breasts, hypothyroidism,
low back pain, and hemorrhoids – is reported with the goal of inspecting whether individualized
homeopathy plays a role in the management of multimorbidity.
Case Presentation
A 35-year-old woman, tall statured, moderately built, and fair complexioned, visited
the Lifestyle Disorders clinic, a co-located AYUSH set-up at the Community Health
Centre, Nandigama, Krishna District, Andhra Pradesh, India, on August 6, 2018 with
the complaints, in order of their appearance, of (1) mass per rectum diagnosed as
hemorrhoids (ICD 10 N: K64.1); (2) pain in the lower back region (ICD 10 N: M54.5);
(3) diagnosed hypothyroidism (ICD 10 N: E03.9); (4) painful lumps in both breasts,
diagnosed as bilateral fibroadenosis (ICD 10 N: D24); and (5) profuse, irregular menses
(every 2 months) with concurrent pain in lower abdomen, diagnosed as fibroid uterus
(ICD 10 N: D25).
History of Presenting Complaints
The patient had noticed a mass per rectum five and a half years earlier, along with
bleeding and a dull, aching pain during defecation. The mass retracted on its own
following defecation. She also suffered from low back pain which was aggravated by
motion and exertion. In early 2017, she entered an early stage of hypothyroidism,
as per laboratory reports ([Table 1]). She was treated with Thyronorm 25 mg once a day for 1 year after her diagnosis, after which she was referred for
homeopathic treatment by a conventional physician. The patient also had persistent
pain in her left breast, which worsened during menses and was aggravated by the slightest
touch or jarring. Her breast pain was treated with analgesics, but the alleviation
was only temporary. Later, pain in the right breast emerged, with recurrence in the
left breast. Pain became more pronounced in the right breast and was diagnosed as
fibroadenosis according to ultragraphy (USG) ([Table 1]). In the meanwhile, she had been experiencing a profuse menstrual flow along with
a dull ache in her lower abdomen. Since then, menses had become profuse, dark, and
clotted, with irregular cycles of approximately 2 months. In the USG pelvis, a bulky
uterus with a fibroid sized 1.8 × 1.1 cm was discovered ([Table 1]). She also complained of persistent lethargy, with decreased desire to perform daily
household activities.
Table 1
Details of the timeline of follow-up
|
Date
|
Indications for prescription
|
Findings of laboratory investigations
|
Medicine with dose and repetition
|
|
August 6, 2018
|
LMP = July 30, 2018 (History of menstrual cycles: May 26, 2018, April 11, 2018), profuse,
delayed, and irregular menses; painful lumps on both breasts (pain in the right breast
more prominent than the left breast; appeared first in the left breast); lethargy;
hemorrhoids with bleeding and aching in the rectum while defecating; low backache;
restlessness; and agitation while conversing about relatives.
|
Thyroid function test
• T3–0.139 μg/dL [0.06–0.2 μg/dL], T4–12.3 μg/dL [4.5–12.0 μg/dL], TSH: <0.01 μIU/mL
[0.30–5.5 μIU/mL]. (Date: January 7, 2017)
• T3: 0.112 μg/dL [0.08–0.2 μg/dL], T4: 8.21 μg/dL [5.1–14.1 μg/dL], TSH: 9.57 μIU/mL
[0.27–4.2 μIU/mL]. (Date: July 13, 2017)
Ultrasound breasts. February 22, 2017: Diffuse prominent fibro glandular tissue with few homogeneous
hypoechoic nodules noted in both breasts with right >left. (Date: February 22, 2017)
Ultrasound of whole abdomen
April 4, 2017: Mildly bulky uterus with 1.8 × 1.1 cm fibroid in posterior myometrium.
(Date: April 1, 2017)
|
Lachesis 200c: one dose. Sac lac for 1 month. Patient continued with Thyronorm 25 mg.
|
|
September 3, 2018
|
LMP: September 1, 2018; menses were on time and normal flow; pain in breast lumps
persisted; occasional tiredness; pain in anus on defecation but bleeding per rectum
on and off; low backache; full of resentments, much as before the initial prescription.
|
–
|
Sac lac for 1 month. Patient continued with Thyronorm 25 mg.
|
|
October 8, 2018
|
LMP: September 29, 2018; menses were regular, profuse with pain in the lower abdomen
and low back; pain of reduced intensity was present in breast lumps; hemorrhoidal
pain was same; tiredness better; lethargy absent.
|
–
|
Sac lac for 1 month. Patient continued with Thyronorm 25 mg.
|
|
November 20, 2018
|
LMP: October 26, 2018; menses were profuse; painful hemorrhoids; pain in breast lumps
lessened; low back pain reduced as it no longer occurred on motion but only after
exertion; lethargy on and off; tiredness was absent, and she had a few fearful dreams
whose details she did not remember on waking up.
|
–
|
Patient continued with Thyronorm 25 mg.
|
|
January 9, 2019
|
LMP: December 25, 2018; menses were delayed, normal flow; patient noticed a reduction
in the size of breast lumps, with on and off occurrence of pain; hemorrhoidal pain
on defecation was reduced in intensity; occasional low back pain and lethargy.
|
–
|
Sac lac for 1 month. Patient stopped Thyronorm 25 mg voluntarily.
|
|
February 11, 2019
|
LMP: January 24, 2019; menses were regular, with normal flow; lower abdominal pain
occurred during last menses; pain in breast lumps recurred, aggravated by touch; profuse
bleeding hemorrhoids thrice in the previous month; back pain was improving slightly;
lethargy only during menses.
|
–
|
Lachesis 200c: one dose. Sac lac for 2 weeks.
|
|
March 19, 2019
|
LMP: March 27, 2019; improved menstrual flow and quantity, reduced abdominal pain;
the size of the breast lumps seemed reduced with no tenderness; reduced low back pain;
hemorrhoidal pain without bleeding on defecation; reduced tiredness, patient started
participating in household chores with interest, unlike earlier; while following up
on the case, she appeared less thoughtful about relative's behavior; she was calm
and composed.
|
–
|
Sac lac for 1 month.
|
|
April 27, 2019:
|
LMP: April 25, 2019; general condition was better; pain in hemorrhoids became better,
with no bleeding per rectum on defecation; her menstrual flow was regular; no tiredness;
the patient could perform all her household chores properly; mental symptoms improved.
|
–
|
Sac lac for 1 month.
|
|
July 8, 2019:
|
LMP: June 21, 2019; regular menses during last 4 months; pain in the lower abdomen
on and off during menses; dark and normal quantity of menstrual flow; no palpable
breast lumps; slight back pain persisted; the patient was referred for ultrasound
breasts and abdomen.
|
–
|
Sac lac for 1 month.
|
|
August 21, 2019
|
LMP: July 27, 2019; general condition was better; no menstrual complaint; low back
pain improved; hemorrhoidal pain reduced without rectal bleeding.
|
Ultrasound of breasts:
Regressed lumps in breasts—normal study. (Date: August 20, 2019)
Ultrasound of whole abdomen:
Reduction in size of the fibroids, i.e., 1.4 × 0.8 cm. (Date: August 20, 2019)
|
Sac lac for 1 month.
|
|
September 16, 2019
|
The patient was being monitored for thyroid complaints and hemorrhoids; she had no
menstrual complaints; she started attending gatherings that involved her relatives;
she grew hopeful about the possibility of purchasing a new home rather than resenting
about a housing dispute.
|
–
|
Sac lac for 1 month.
|
|
October 26, 2019
|
General condition improved; low back pain intensity lessened; occasional hemorrhoidal
pain without bleeding.
|
–
|
Sac lac for 1 month.
|
|
December 2, 2019
|
General condition better, but back pain persisted with exertion; hemorrhoidal pain
and rectal bleeding were absent.
|
–
|
Sac lac for 1 month.
|
|
January 2, 2020
|
General condition better; Tiredness was reduced. No hemorrhoidal pain or rectal bleeding;
improved back pain.
|
Thyroid function test:
T3: 0.093 μg/dL [0.07–0.2 μg/dL], T4: 9.72 μg/dL [4.6–10.5 μg/dL], TSH: 6.49 μIU/mL
[0.4–4.5 μIU/mL]. (Date: December 28, 2019)
|
Sac lac for 1 month.
|
|
February 11, 2020
|
No menstrual complaint; lethargy was reduced; low back pain was better and hemorrhoidal
pain was on and off; the patient was referred for thyroid function test and ultrasound
whole abdomen.
|
–
|
Sac lac for 1 month.
|
|
October 29, 2020
|
Palpitations and tiredness persisted occasionally; low back pain improved; hemorrhoidal
pain during defecation.
|
Ultrasound of whole abdomen:
Small uterine fibroid measuring 1 × 0.6 cm in size. (Date: October 20, 2020)
Thyroid function test:
TSH: 6.93 μIU/mL [0.550–4.780 μIU/mL] (Date: October 9, 2020)
|
Thyroidinum 6c, 4 pills, once daily for 1 month.
|
|
December 3, 2020
|
Occasional tiredness while performing household chores; palpitations on exertion;
hemorrhoidal pain during defecation; low back pain was better; no menstrual complaint.
|
–
|
Thyroidinum 6c, once daily for 2 months.
|
|
March 15, 2021
|
General condition was better; reduced tiredness; reduced palpitations; hemorrhoidal
pain was reduced in intensity but persisted; the patient was calm and composed; thyroid
profile test was suggested.
|
–
|
Sac lac for 1 month.
|
|
May 7, 2021
|
Hemorrhoidal pain did not occur with every episode of defecation; low back pain improved;
reduced anxiety; the patient became more hopeful and less worried about the past.
|
Thyroid function test:
T3: 1.17 ng/mL [0.60–1.81 ng/mL], T4: 8.0 μg/dL [4.5–12.6 μg/dL], TSH: 3.81 μIU/mL
[0.35–5.50 μIU/mL]. (Date: May 3, 2021)
|
Sac lac for 1 month.
|
Abbreviations: LMP, last menstrual period; T3, triiodothyronine; T4, tetra-iodothyronine;
TSH, thyroid-stimulating hormone.
Personal History
Menarche occurred at the age of 13 years. Her menses had been regular since then until
her complaints began. She prefers a non-vegetarian diet and has no tobacco, alcohol,
or other stimulant addictions.
Life and Accessory Circumstances
The patient was born and brought up in a family of low socio-economical strata. While
conversing about her family, with whom she had resentments over a housing dispute,
she became agitated and restless. The patient had a history of grief due to changing
her house after a conflict with relatives 5 years ago. She is adamant about reclaiming
her home, for which she also threatened to retaliate against her relatives if the
house was not returned. She wished for her families' pain or accidents. She was envious
of her relatives' improving economic status. She refused to let her husband and children
visit their relatives because she was afraid they would be poisoned. She avoided all
gatherings in which those relatives were involved.
Mind and Disposition
-
Anxiety and fear of ghosts and evil.
-
Fear of being poisoned.
-
Maliciousness.
-
Ailments from grief and betrayal.
-
Desires company during the time of her complaints.
-
Revengeful.
-
Suspicion toward relatives.
Physical Generals
Thermal reaction: hot patient; desire for cold food and drinks.
Clinical Findings
A palpable, smooth, hard, and tender lump, approximately 4 cm in diameter, was discovered
in the left breast during a physical examination. Another lump with similar characteristics
was identified in the right breast measuring 3 cm in diameter. The lumps in both breasts
appeared to be surrounded by diffused swelling.
Diagnostic Assessment
The patient was diagnosed with multimorbidity, which included hypothyroidism, fibroadenosis
in both breasts and fibroid uterus (based on ultrasound of the breasts and pelvis
respectively), as well as thyroid function tests (triiodothyronine [T3], tetra-iodothyronine
[T4], thyroid-stimulating hormone [TSH]). Clinical examination and clinical features
indicated the presence of second-degree hemorrhoids and low back pain.
Therapeutic Intervention
Based on the totality of symptoms and a reportorial analysis performed by using Repertory
software, Cara 1.4 ([Fig. 1]), the first five medicines with the number of rubrics covered and the grades of
each medicine were Lachesis (8/17), Belladonna (7/13), Calcarea carb (7/13), Phosphorus (7/16), and Arsenicum
album (6/14). Differentially, Belladonna is predominantly a right-sided medicine, and it does not address the patient's symptoms
of revengefulness and hatred. It is the medicine given for sudden, violent onset.
Calcarea carb patients are leuco-phlegmatic, fat, and perspiring individuals who are forgetful,
apprehensive, and get worse from cold in every form, which did not match the lean,
thin build, and mental symptoms of the patient. Phosphorus is a medicine for hemorrhage, and it is suitable for bright red menses that appear
too early and are long-lasting and scanty. The burning sensation is marked as a keynote
symptom of this medicine. Phosphorus patients, like the patient in this study, desire company but are neither revengeful
nor malicious. While some of the symptoms of Arsenicum album, such as maliciousness, tiredness, restlessness and anxiety, matched the patient's
complaints, other symptoms such as burning sensation, fear of death, fastidiousness
and early menses did not.[17]
Fig. 1 Repertorial sheet from Repertory software version Cara 1.4 (Repertorial chart = Lachesis: 8/17, Belladonna: 7/13, Calcarea carbonica: 7/13, Phosphorus: 7/16, Arsenicum album: 6/14).
Furthermore, a keynote symptom of Lachesis wherein “diseases begin on the left and go to the right side” was justified by the
appearance of pain in the left breast that proceeded to the right breast.[18] The patient mentioned that she had not been well since the series of events that
occurred during her house dispute (fights with relatives).[18] Likewise, Lachesis is suitable for a woman who has not recovered from the change of life: “I have never
felt well since that time”. Lachesis is a hot patient, malicious, suspicious and restless, with ailments appearing from
long-lasting grief. Lachesis has a marked hemorrhagic tendency, protruding hemorrhoids during stool, dark menstrual
blood, swelling in the mammary glands, anxiety, and fear of being poisoned.[17]
[19] Based on the above, the patient received the individualized homeopathic treatment
Lachesis mutus 200c (one dose), four globules moistened with medicine, and given orally. The patient
was also advised lifestyle modifications such as regular exercise, yoga, increased
consumption of a high fiber diet, and avoiding fried food.
Follow-up and Outcome
During follow-ups, the repeat USG-breasts and lower abdomen, plus thyroid function
test, revealed marked overall improvement. Menses became regular, the uterine fibroid
decreased in size, and TSH levels decreased. Further, the homeopathic remedy Lachesis ameliorated pain in both breasts, followed by regression of breast lumps. After the
patient voluntarily discontinued the Thyronorm in January 2019 her symptoms steadily
decreased but the TSH levels nevertheless increased after a period of 1 year, which
led to the prescription of Thyroidinum 6c (4 pills, once daily) for 3 months. Symptoms of the patient, such as weakness,
easy fatigue, uterine fibroids, fibroid tumors of the breast and hypothyroidism, concurred
with those of Thyroidinum.
[17]
[19] Considering the homeopathic principle of prescribing one simple medicine at a time
to a patient, the homeopathic medicine Thyroidinum 6c was not given concurrently with Lachesis during the follow-up period. Thereafter, placebo was continued soon after improvement
was observed in the patient ([Table 1]). This shows the complete coverage capacity of an individualized homeopathic remedy,
selected on the totality of symptoms according to homeopathic principles. This case
study has been drafted in conformity with the HOM-CASE guidelines for clinical case
reporting ([Supplementary Table S1], available online only).[20]
[21] The patient signed a consent form permitting her medical images and other clinical
information to be published anonymously in an academic journal. The patient expressed
understanding that her name and initials would not be published, and that all due
efforts would be made to conceal her identity.
MONARCH Inventory Score
The MONARCH inventory[20]
[21] applied in this case study showed a total score of (10/(13 ([Table 2]). Details of the positive scores are as follows: criteria 1, 2, 4, and 5 (improvement
in general well-being of the patient as assessed by interview with the patient on
multiple visits); criterion 6A (fibroid uterus was last to appear and improved first;
afterward breast fibroadenosis was reduced in size and thyroid function tests showed
improvement; both of which came before fibroid uterus in order); criterion 8 (no other
medication intake during homeopathic treatment, though lifestyle modifications were
advised but as an adjunct); criterion 9 (regression of breast lumps and fibroid uterus
confirmed by USG scan reports during homeopathic treatment; TSH levels were reduced
during homeopathic treatment); and criterion 10 (a clinical improvement on repeat
dosing). Based on the MONARCH score, it can be concluded that there is some evidence
to attribute a causal link between the treatment and the clinical improvement in the
patient.
Table 2
MONARCH Inventory (improved version of the Modified Naranjo Criteria for Homeopathy).
Maximum possible score = +13, minimum score = − 6
|
No.
|
Domain
|
Grading of response to medication
|
|
Yes
|
No
|
Not sure
|
|
1
|
Was there an improvement in the main symptom or condition for which the homeopathy
medicine was prescribed?
|
+2
|
−1
|
0
|
|
2
|
Did the clinical improvement occur within a plausible timeframe relative to the medicine
intake?
|
+1
|
−2
|
0
|
|
3
|
Was there a homeopathic aggravation of symptoms?
|
+1
|
0
|
0
|
|
4
|
Did the effect encompass more than the main symptom or condition (i.e., were other
symptoms, not related to the main presenting complaint, improved or changed)?
|
+1
|
0
|
0
|
|
5
|
Did overall well-being improve? (Suggest using a validated scale or mention about
changes in physical, emotional, and behavioral elements)
|
+1
|
0
|
0
|
|
6A
|
Direction of cure: did some symptoms improve in the opposite order of the development
of the symptoms of the disease?
|
+1
|
0
|
0
|
|
6B
|
Direction of cure: did at least two of the following aspects apply to the order of
improvement of symptoms:
• from organs of more importance to those of less importance?
• from deeper to more superficial aspects of the individual?
• from the top downwards?
|
+1
|
0
|
0
|
|
7
|
Did “old symptoms” (defined as non-essential and non-clinical symptoms that were previously
thought to have resolved) reappear temporarily during the course of improvement?
|
+1
|
0
|
0
|
|
8
|
Are there alternative causes (i.e., other than the medicine) that—with a high probability—could
have produced the improvement? (Consider known course of disease, other forms of treatment,
and other clinically relevant interventions).
|
−3
|
+1
|
0
|
|
9
|
Was the health improvement confirmed by any objective evidence? (e.g., investigations,
clinical examination, etc.)
|
+2
|
0
|
0
|
|
10
|
Did repeat dosing, if conducted, create similar clinical improvement?
|
+1
|
0
|
0
|
|
Total score
|
+10
|
Note: The score for each item is shown in bold.
Patient Perspective
The patient reports that she is feeling healthier, more active, and has a sense of
mental peace. She says, “I feel very happy that after taking homeopathic treatment
for the uterine problem and breast lumps, no surgery was required, and I feel healthier
and energetic while doing my household work”. She says she is sleeping peacefully
and feels comfortable about herself, in contrast to her previous state of mind when
she experienced disturbed sleep while thinking about her surgery. After being referred
by her conventional doctor to homeopathy for management of her condition, she was
relieved of her physical complaints as well as the anxiety. She mentions that her
homeopathic doctor enquired about all her complaints in detail and gave her encouragement
along with medicines. She says, “My physical complaints were subsiding and later,
when I self-examined my breasts as instructed by my doctor, I noticed that the size
of nodes had reduced. This was confirmed when my breast ultrasound report revealed
a normal picture. I am very happy that no surgery was required thereafter”. She says
that her anxiety and her resentments toward relatives are well controlled, with a
reduced sense of suspicion and vengeance toward them. She ended her remarks by stating
that all of her complaints had gradually faded away, and she was satisfied that her
mind was also at peace.
Discussion
The homeopathic system of medicine is based on the “Law of Similars”. It means that
the symptoms produced by a homeopathic medicine in a healthy individual are similar
to those of the disease condition to be treated. The most similar and suitable medicine
is prescribed based on the totality of symptoms, in singular and simple form, to treat
people who are sick, not the diseases in themselves.[22] On the other hand, conventional health care systems revolve around specialized disciplines
and the identification and management of individual conditions.[4] Moreover, medical research traditionally focuses on understanding and developing
treatments for individual conditions. Thus, multimorbidity presents a profound challenge
to the way medicine is delivered, taught, and researched.[4]
However, this case under study suggests that homeopathic treatment can be beneficial
in cases of multimorbidity, including fibroid uterus, fibroadenosis breasts, hypothyroidism,
hemorrhoids, and low back pain. In this case study, a complete patient picture was
elicited through the physician's observations and the patient's symptoms, as well
as laboratory measures such as abdominal USG, breast USG, thyroid function tests,
and clinical examination. The patient's symptomatology and pathological abnormalities
improved over a 33-month period, according to laboratory parameters. Additionally,
the MONARCH score attributed to the treatment implies a link between the medicines
prescribed on the basis of homeopathic principles and the clinical improvement in
the patient.
Keeping in view that elderly patients are more likely to develop multimorbidity, an
observational study by Teut et al[23] demonstrated that elderly individuals with long-standing chronic diseases seek homeopathic
treatment and that the severity of their complaints reduced significantly in the first
3 months after beginning treatment.
Multimorbidity is posing a widely recognized challenge to the whole medical profession,
from primary care to acute and long-term hospital treatment.[24] Single-disease clinical practice guidelines (CPGs) are not designed to consider
patients with multiple chronic conditions or multimorbidity.[25] Furthermore, following different CPGs would make treatment time-consuming, costly,
and disruptive.[25] Moreover, applying multiple CPGs on a single patient may create an overwhelming
treatment burden, which can lead to poor compliance and clinical outcomes.[25] The three broad challenges identified for treating multimorbidity are: (1) defining
and measuring multimorbidity; (2) effects of multimorbidity on study design, implementation,
and analysis; and (3) difficulties inherent in studying heterogeneity of treatment
effects in patients with differing co-morbid conditions.[26]
[27]
In a systematic review of 600 research studies, it was found that RCTs testing behavioral
interventions rarely consider individuals with multi-morbidity.[28] Placebo-controlled RCTs are considered the “gold standard” of evidence but they
may have drawbacks in terms of external validity, especially when it comes to multimorbidity.[29] As a result, it may be necessary to apply a broader range of research methods that
can provide converging evidence on treatment effects to address multiple chronic conditions.[29] At this juncture, pragmatic RCTs or comparative effectiveness studies are recommended
for such research. Pragmatic trials, such as in the cohort multiple RCT design where
"treatment as usual" is compared with the offer of study treatment, study patients
in a “real world” setting and tend to emphasize patient-reported outcome measures.[30] The present case report can be seen as contributory to that evidence building on
the role of homeopathic management in multimorbidity.
