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Synlett 2023; 34(13): 1554-1562
DOI: 10.1055/s-0042-1751429
DOI: 10.1055/s-0042-1751429
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Advances in Selected Heterocyclization Methods
The authors thank the National Institutes of Health (NIH, GM120281 and F31GM139395), the National Science Foundation (CHE-1955663), the Welch Foundation (Chair, AT-0041) and the Eugene McDermott Graduate Fellowship (202007) for financial support.
Abstract
This Account summarizes efforts in our group toward synthesis of heterocycles in the past decade. Selected examples of transannulative heterocyclizations, intermediate construction of reactive compounds en route to these important motifs, and newer developments of a radical approach are outlined.
1 Introduction
2 Transannulative Heterocyclization
2.1 Rhodium-Catalyzed Transannulative Heterocyclization
2.2 Copper-Catalyzed Transannulative Heterocyclization
3 Synthesis of Heterocycles from Reactive Precursors
3.1 Synthesis of Heterocycles from Diazo Compounds
3.2 Synthesis of Heterocycles from Alkynones
4 Radical Heterocyclization
4.1 Light-Induced Radical Heterocyclization
4.2 Light-Free Radical Heterocyclization
7 Conclusion
Key words
transannulative heterocyclization - heterocycles - radical heterocyclization - transition-metal-catalyzed heterocyclization.Publication History
Received: 23 December 2022
Accepted after revision: 13 February 2023
Article published online:
10 March 2023
© 2023. Thieme. All rights reserved
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