Synthesis and Optical Resolution of Inherently Chiral Fluorescent Calix[4]arenes and Their Application in Chiral Recognition

Fu-Ming Yang; Jun Luo; Yi-Chieh Chen; Wen-Sheng Chung

doi:10.1055/s-0042-1751455

Synthesis, Table of Contents

Synthesis 2023; 55(17): 2786-2796
DOI: 10.1055/s-0042-1751455

paper

Special Issue Honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry

Synthesis and Optical Resolution of Inherently Chiral Fluorescent Calix[4]arenes and Their Application in Chiral Recognition

Fu-Ming Yang

^aDepartment of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 30050

,

Jun Luo∗

^aDepartment of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 30050

^bTongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, P. R. of China

,

Yi-Chieh Chen

^cDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan 30050

,

Wen-Sheng Chung ∗

^aDepartment of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan 30050

^cDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu, Taiwan 30050

› Author Affiliations

Abstract

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This paper is dedicated to Prof. Guoqiang Lin on the occasion of his 80^th birthday, for his great contribution to organic chemistry in China.

Abstract

Inherently chiral calix[4]arenes were separated by condensation with chiral auxiliary (S)- and (R)-1-phenylethylamine using column chromatography on silica gel; subsequent derivatization with click chemistry furnished compounds with fluorescent properties that can be used for chiral recognition.

Key words

calix[4]arene - inherently chiral - click chemistry - fluorescent sensors - chiral resolution

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References

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