Asymmetric Allylic Substitution Reactions Based on Relay Catalysis

Zhenwei Wu; Xiaoming Feng; Yangbin Liu

doi:10.1055/s-0042-1751568

Synthesis, Table of Contents

Synthesis 2024; 56(22): 3349-3364
DOI: 10.1055/s-0042-1751568

short review

Dual Catalysis

Asymmetric Allylic Substitution Reactions Based on Relay Catalysis

Zhenwei Wu

^aInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, 518055, P. R. of China

,

Xiaoming Feng∗

^aInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, 518055, P. R. of China

^bKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. of China

,

Yangbin Liu∗

^aInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen, 518055, P. R. of China

› Author Affiliations

Abstract

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Abstract

Transition-metal-catalyzed asymmetric allylic substitution reactions represent a hot research topic in the field of asymmetric synthesis, with significant progress having been made. Among diverse catalysis systems, relay catalysis enables sequential activation of multiple steps in one pot and the rapid construction of multiple chiral centers, providing a simple and powerful platform for organic synthesis. Recently, relay catalysis has been successfully applied to asymmetric allylic substitution reactions, and a variety of challenging transformations have been realized. This Short Review summarizes the related progress on asymmetric allylic substitution reactions based on relay catalysis over the last decade.

1 Introduction

2 The General Transformation Model

3 Allylation Relays Further Reaction

4 Initial Reaction Relays Allylation

5 Conclusion and Outlook

Key words

asymmetric catalysis - allylic substitution - relay catalysis - transition metal - asymmetric transformation

Full Text

References

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