Keywords
heart failure - minimally invasive surgery (includes port access, minithoracotomy)
- wound healing
Introduction
According to the current clinical guidelines, cardiac resynchronization therapy device
with defibrillator (CRT-D) implantation is indicated for patients with a history of
malignant ventricular arrhythmias, symptomatic heart failure, wide QRS, or high-degree
atrioventricular block.[1] However, there are certain conditions where the standard implantation approach is
not applicable due to congenital or acquired conditions.
Case Description
A patient with dilated cardiomyopathy underwent conventional CRT-D implantation using
left subclavian vein access following a successful resuscitation due to ventricular
tachycardia. One month later skin necrosis was detected above the device. Our hypothesis
was that burn injury—which he suffered 40 years prior—has damaged the microcirculation
of the skin and was accountable for the necrosis. The complete system was explanted,
and we utilized negative pressure wound therapy for the treatment of the remaining
tissue ([Fig. 1]).
Fig. 1 (A) Three weeks after the implantation. (B) The complete system was removed, and a large tissue gap remained. (C) Negative pressure of 125 mm Hg was applied, to cover the tissue defect and facilitate
tissue regrowth. (D) Three weeks after the device explantation. With continuous negative pressure wound
therapy, the absence of skin tissue was almost completely closed.
We decided to perform surgical reimplantation of the device using minithoracotomy:
right atrial and right ventricular leads were introduced through the right atrial
appendage and the left ventricular lead was inserted transapically.
Surgical Technique
For minithoracotomy, a vertical right lateral 5.5 cm long skin incision was made over
the fourth right intercostal space just anterior to the midaxillary line. Single-lung
ventilation was initiated, and the right lung was retracted posteriorly. The pericardium
was carefully opened.
A guidewire was inserted with Seldinger's technique through the puncture of right
appendage into the right atrium. The wire was then exchanged to a sheath and a right
ventricular shock electrode was introduced. Eventually, it was positioned and secured
to the right ventricular apex under fluoroscopy guidance with good electrode parameters.
The right atrial lead was also introduced with the same method and positioned with
a J-shaped stylet into the anterior part of the right auricle. Bleeding was controlled
and the electrodes were secured with purse-string sutures around the puncture points
([Fig. 2A]).
Fig. 2 Surgical cardiac resynchronization therapy device with defibrillator (CRT-D) implantation.
(A) Right lateral minithoracotomy. The right ventricular and right atrial leads are
positioned and fixed with purse-string sutures. (B) Left lateral minithoracotomy. The left ventricular lead was introduced through the
apex of the left ventricle. (C) The leads were pulled through tunnels into the abdominal part and attached to the
CRT-D device. (D) Positioning of the leads was performed with fluoroscopy guidance. (E) Good parameters were recorded at the end of the procedure. (F) Six months after the surgery.
Next, the ideal site for the incision to reach the apex of the left ventricle (LV)
was identified and marked by transthoracic echocardiography guidance at the corresponding
intercostal space. A second minithoracotomy was performed on the left side of thorax.
A guidewire was inserted with Seldinger's technique through the puncture of the apex
into the LV. After removal of the guidewire, the pacing electrode was inserted into
the LV cavity through the sheath and peel-off sheath was removed. Bleeding from the
LV was controlled with purse-string sutures around the puncture point ([Fig. 2B]). Fluoroscopy was utilized for the endocardial fixation of the electrode at the
lateral wall of the LV ([Fig. 2D]).
The device was implanted in the abdominal area, where the skin was almost intact,
below the diaphragm and the electrodes were tunneled ([Fig. 2C]) ([Video 1]). Anticoagulation was initiated because of the foreign body in the LV. Six months
later there was no sign of complications, and the surgical wounds healed completely.
Video 1 Steps of the procedure presented in the video: right axillary minithoracotomy, fixing
RA and RV leads, left axillary minithoracotomy and introduction of LV lead, making
the infraclavicular pocket, tunneling the electrodes, closing the wound. LV, left
ventricle; RA, right atrium; RV, right ventricle.
Discussion
CRT is a well-established therapy for patients with heart failure and ventricular
dyssynchrony. The side branches of the coronary sinus are the first choice of sites
for left ventricular lead implantation. However, biventricular pacing does have some
challenges, including high pacing threshold, unavoidable phrenic nerve stimulation,
the rate of nonresponders and rarely, chest deformities, and the rate of unsuccessful
implantation. Several minimally invasive alterative implantation techniques have been
developed.[2]
[3] Techniques, involving transvenous approach, cannot be obtained in our case because
the reimplantation of the device in the conventional subclavicular region was not
possible. Several authors recommend pocket change and subpectoral placement, but the
skin could not be sutured properly as a result of the previous burn injury. Transfemoral
lead insertion with CRT-P implantation was also reported, but this technique cannot
be adopted for a patient requiring an implantable cardioverter defibrillator.[4] Therefore, we chose a surgical, but minimally invasive approach for implanting the
leads. With our approach, some similarly challenging cases of complex device implantations
can be successful.
Lifelong anticoagulation was initiated after the procedure with a target international
normalized ratio level equivalent to mitral prosthetic valves (2.5–3.5). This approach
is not an option for patients with contraindication to anticoagulation. For them the
only possible solution is the epicardial implantation (if the conventional transvenous
also failed).
We successfully applied the combination of transatrial and transapical lead placement
in a CRT-D device, which has not been reported in the literature yet. It serves as
an alternative method in selected cases, where the standard approach is not feasible.
