OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

Dinh-Toi Chu; Yang Tao; Kjetil Taskén

doi:10.1055/s-0043-100384

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2017; 49(04): 276-285
DOI: 10.1055/s-0043-100384

Review

OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

Dinh-Toi Chu

¹Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway

²Institute for Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam

³Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam

⁴College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China

,

Yang Tao

⁴College of Food Science and Technology, Nanjing Agricultural University, Nanjing, China

,

Kjetil Taskén

¹Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway

⁵K. G. Jebsen Inflammation Research Centre; University of Oslo, Oslo, Norway

⁶Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway

› Author Affiliations

Abstract

OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.

Key words

OPA1 - AKAP - cAMP - lipid metabolism - brown adipocyte - white adipocyte

Full Text

References

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