Immuntherapien beim fortgeschrittenen NSCLC

Martin Reck; Wolfgang Schütte; Nicolas J. Dickgreber; Niels Reinmuth; Thomas Wehler; Stefanie Morris; Achim Rittmeyer; Wilko Weichert

doi:10.1055/s-0043-122013

TumorDiagnostik & Therapie, Table of Contents

TumorDiagnostik & Therapie 2018; 39(06): 371-384
DOI: 10.1055/s-0043-122013

Thieme Onkologie aktuell

Immuntherapien beim fortgeschrittenen NSCLC

Neue Entwicklungen durch Immuntherapien mit Checkpoint-Inhibitoren und ihre Implikationen für die klinische PraxisImmunotherapies in advanced NSCLCNew developments by immunotherapies with checkpoint-inhibitors and their implications for clinical practice

Martin Reck

¹LungenClinic Grosshansdorf

,

Wolfgang Schütte

²Krankenhaus Martha-Maria Halle-Dölau

,

Nicolas J. Dickgreber

³Mathias-Spital Rheine

,

Niels Reinmuth

⁴Asklepios Fachkliniken München-Gauting

,

Thomas Wehler

⁵Universitätsklinikum des Saarlandes

,

Stefanie Morris

⁶Roche Pharma AG Grenzach-Wyhlen

,

Achim Rittmeyer

⁷Lungenfachklinik Immenhausen

,

Wilko Weichert

⁸Institut für Pathologie, Technische Universität München

› Author Affiliations

Abstract

Zusammenfassung

Der Einzug von Immuntherapien mit Checkpoint-Inhibitoren in die Behandlung des fortgeschrittenen nicht kleinzelligen Lungenkarzinoms (NSCLC) hat die Erst- und Zweitlinientherapie revolutioniert. Nach langem therapeutischem Stillstand für die große Gruppe von Patienten ohne therapierbare Treibermutationen stehen nun erstmals neue Behandlungsoptionen zur Verfügung. Aktuell werden Kombinationstherapien geprüft, die das Potenzial der Immuntherapien noch besser ausschöpfen sollen. Für den Kliniker heißt das aber auch, dass die Therapieentscheidungen beim metastasierten NSCLC immer komplexer werden. Daher möchte die vorliegende Publikation vor allem folgende Fragen beantworten: Wie verändern die aktuell etablierten Immuntherapien unser Vorgehen in der klinischen Praxis? Welche Kriterien eignen sich zur Auswahl geeigneter Therapieschemata? Welche Herausforderungen müssen zukünftig noch gemeistert werden?

Abstract

The approval of immunotherapies has revolutionized the first and second line therapy of advanced non-small cell lung cancer (NSCLC). For a long time, no potent treatment was available for a large group of patients with NSCLC without treatable driver mutations. Now novel treatment options have become available for this group. Combination therapies aiming at further extending the potential of immunotherapies are currently under investigation. For clinicians, this also means that decision making in treating metastatic NSCLC is getting much more complex. Thus, the aim of the present publication primarily is to answer the following questions: How do immunotherapies change our procedures in clinical practice? Which criteria are appropriate for choosing the right treatment schedules? Which challenges have to be managed in the near future?

Schlüsselwörter

NSCLC - Immuntherapie - Checkpoint-Inhibitoren

Key words

non-small cell lung cancer - immunotherapy - immune checkpoint inhibitor

Full Text

References

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