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Drug Res (Stuttg) 2018; 68(06): 311-316
DOI: 10.1055/s-0043-122490
Review
© Georg Thieme Verlag KG Stuttgart · New York

Recent Progresses in Breast Reconstruction: Stem Cells, Biomaterials, and Growth Factors

Farshad Zarei
1   Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
,
Hadis Daraee
2   Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical sciences, Tehran, Iran
› Author Affiliations
Further Information

Publication History

received 13 August 2017

accepted 07 October 2017

Publication Date:
04 December 2017 (online)

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Abstract

Breast cancer is one of the most deadly tumors in women, and new procedures for post- surgical breast reconstruction have been developed which includes autologous stromal vascular fraction (SVF), platelet-derived growth factors, biomaterials and various stem cells. Adipose derived-stem cells (ASCs) has been reported to be one of the most widely used stem cell for breast reconstruction because of their ability to form new functional adipose tissue and vessels and in combination with stromal vascular fraction has been also reported efficient for breast reconstruction. Biomaterials include acellular dermal matrix, bone substitutes, and injectable have also been reported to be applicable for several clinical applications, including breast reconstruction surgery. Nevertheless, further studies are needed to explicitly define methodological procedures and to confirm the safety of all theses procedures during post-surgical breast reconstruction. The purpose of this mini-review is to summarize various recent and old applications of stem cells, biomaterials as well as growth factors in breast reconstruction.

Key words

Stem cells - biomaterials - breast reconstruction - growth factors - stromal vascular fraction - Adipose derived-stem cells (ASCs)
 

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