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DOI: 10.1055/s-0043-1767708
The Progress of Colorectal Polyposis Syndrome in Chinese Population
Funding This work was supported by the Provincial Key R&D Program of Zhejiang Province (2021C03125).![](https://www.thieme-connect.de/media/ccrs/202306/lookinside/thumbnails/10-1055-s-0043-1767708_01268-1.jpg)
Abstract
The pathogenesis, clinical phenotype, treatment strategy, and family management of hereditary tumor syndromes are different from those of sporadic tumors. Nearly a quarter of patients with colorectal cancer show significant familial aggregation and genetic predisposition, and 5 to 10% are associated with definite genetic factors. According to the clinical phenotype, it can be divided into nonpolyposis syndrome and polyposis syndrome. Among the polyposis syndrome patients with definite clinical symptoms, there are still some patients with unknown etiology (especially attenuated familial adenomatous polyposis), which is a difficult problem in clinical diagnosis and treatment. Therefore, for this rare disease, it is urgent to carry out multicenter studies, complete the gene variation spectrum, explore new pathogenic factors, and accumulate clinical experience. This article mainly introduces the research progress and related work of colorectal polyposis syndrome in China.
* Zhijun Yuan and Mengyuan Yang are co-first authors, and they contributed equally to the work.
Publication History
Article published online:
09 April 2023
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