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J Neurol Surg A Cent Eur Neurosurg 2024; 85(03): 254-261
DOI: 10.1055/s-0043-1769004
Original Article

The Early Postoperative Course of Cognitive Function and Preoperative Cerebrovascular Reserve

Masashi Ikota
1   Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, Japan
,
Mami Ishikawa 
1   Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, Japan
,
Gen Kusaka
1   Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, Japan
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Abstract

Background Patients with severe steno-occlusive disease of a main cerebral artery without causative lesions on magnetic resonance imaging (MRI) often develop cognitive impairment. However, the effects of revascularization surgery and the source of the cognitive impairment remain unclear. Therefore, we investigated the early postoperative course of cognitive function and its association with cerebral blood flow (CBF), cerebrovascular reserve (CVR), white matter disease (WMD), lacunar infarction, and cerebrovascular risk factors.

Methods Cognitive function was examined using neurobehavioral cognitive status examination (COGNISTAT) in 52 patients with steno-occlusive disease of a main cerebral artery before and at 6 months after superficial temporal artery–middle cerebral artery (STA–MCA) anastomosis. We examined how cognition changed before and at 1, 3, and 6 months after STA–MCA anastomosis in 27 of 52 patients. CVR and CBF were calculated from 123I-N-isopropyl-p-iodoamphetamine single photon emission computed tomography, in addition to other cerebrovascular risk factors in 34 of 52 patients. Cerebral infarction and WMD (periventricular hyperintensity [PVH] and deep subcortical white matter hyperintensity) were also evaluated preoperatively by MRI.

Results COGNISTAT scores improved at 1 month after STA–MCA anastomosis in patients with severe steno-occlusive disease of a main cerebral artery. Multiple stepwise regression analysis revealed that CVR (regression coefficient = –2.237, p = 0.0020) and PVH (regression coefficient = 2.364, p = 0.0029) were the best predictors of postoperative improvement in COGNISTAT scores (R 2 = 0.415; p = 0.0017).

Conclusion Cognitive function improves in relation to preoperative CVR and PVH early after STA–MCA anastomosis in patients with steno-occlusive disease of a main cerebral artery.

Keywords

cognition - cerebrovascular reserve - cerebral blood flow - regression correlation


Publication History

Received: 05 August 2022

Accepted: 09 January 2023

Article published online:
28 July 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
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